PV basket cell firing rate changes during sharp-wave ripples: healthy vs diseas…

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1098/rstb.2012.0518",
      "value": "strongly increased",
      "method": "juxtacellular recording with post-hoc identification",
      "metric": "PV basket cell firing rate change during SWRs",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "identified interneurons recorded in vivo",
      "scope_region": "hippocampal CA1 and CA3",
      "study_system": "rat/mouse hippocampus CA1/CA3",
      "taxonomic_level": "fine type",
      "scope_population": "PV-expressing basket cells",
      "value_source_sentence": "Parvalbumin-expressing basket cells fire phase locked to field gamma activity in both CA1 and CA3, and also strongly increase firing during SWRs.",
      "experimental_conditions": "healthy, in vivo recordings"
    },
    {
      "n": 0,
      "doi": "10.1523/JNEUROSCI.0425-20.2020",
      "value": "46% reduction",
      "method": "calcium imaging, cell-attached, whole-cell recordings",
      "metric": "PV basket cell spike rate during SWRs",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "PV basket cells recorded during SWRs",
      "scope_region": "hippocampal CA1",
      "study_system": "5xFAD mouse hippocampal CA1 slices",
      "taxonomic_level": "fine type",
      "scope_population": "PV-expressing basket cells",
      "value_source_sentence": "We observed a 46% spike rate reduction during SWRs in PV basket cells (PVBCs), while PV bistratified and axo-axonic cells were unimpaired.",
      "experimental_conditions": "3-month 5xFAD vs controls, ex vivo"
    },
    {
      "n": 0,
      "doi": "10.1016/j.celrep.2021.109970",
      "value": "reduced PV density with altered SWRs",
      "method": "silicon probe LFP, patch-clamp, immunohistochemistry",
      "metric": "PV interneuron density and SWR alteration",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "mice per genotype",
      "scope_region": "hippocampal CA1",
      "study_system": "Cntnap2-/- mouse hippocampus",
      "taxonomic_level": "broad category",
      "scope_population": "all PV interneurons",
      "value_source_sentence": "Cntnap2-/- mice show a reduction in hippocampal PV interneuron density, reduced inhibitory input to CA1 pyramidal cells, and frequency-dependent circuit changes including alterations in gamma oscillations, sharp-wave ripples, and theta-gamma modulation.",
      "experimental_conditions": "Cntnap2 knockout vs controls"
    }
  ],
  "comparison_id": "pv-basket-swr-firing-rate-change",
  "comparison_name": "PV basket cell firing rate changes during sharp-wave ripples: healthy vs disease models",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "PV basket cells show strong SWR activation in healthy hippocampus but selective impairment in AD and ASD models, while other PV subtypes can be spared",
  "homogeneity_check": {
    "caveats": [
      "Different disease models and preparations",
      "Third paper reports all PV cells without subtype distinction"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "true",
    "taxonomic_level_uniform": "false",
    "scope_population_uniform": "false"
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-12b8963c5eea",
  "paper:paper-54726517a4fb",
  "paper:paper-78f33d23c109"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}