Version history

{
  "kind": "infographic",
  "prompt": "PV basket cells show strong SWR activation in healthy hippocampus but selective impairment in AD and ASD models, while other PV subtypes can be spared",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1098/rstb.2012.0518",
        "value": "strongly increased",
        "method": "juxtacellular recording with post-hoc identification",
        "metric": "PV basket cell firing rate change during SWRs",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "identified interneurons recorded in vivo",
        "scope_region": "hippocampal CA1 and CA3",
        "study_system": "rat/mouse hippocampus CA1/CA3",
        "taxonomic_level": "fine type",
        "scope_population": "PV-expressing basket cells",
        "value_source_sentence": "Parvalbumin-expressing basket cells fire phase locked to field gamma activity in both CA1 and CA3, and also strongly increase firing during SWRs.",
        "experimental_conditions": "healthy, in vivo recordings"
      },
      {
        "n": 0,
        "doi": "10.1523/JNEUROSCI.0425-20.2020",
        "value": "46% reduction",
        "method": "calcium imaging, cell-attached, whole-cell recordings",
        "metric": "PV basket cell spike rate during SWRs",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "PV basket cells recorded during SWRs",
        "scope_region": "hippocampal CA1",
        "study_system": "5xFAD mouse hippocampal CA1 slices",
        "taxonomic_level": "fine type",
        "scope_population": "PV-expressing basket cells",
        "value_source_sentence": "We observed a 46% spike rate reduction during SWRs in PV basket cells (PVBCs), while PV bistratified and axo-axonic cells were unimpaired.",
        "experimental_conditions": "3-month 5xFAD vs controls, ex vivo"
      },
      {
        "n": 0,
        "doi": "10.1016/j.celrep.2021.109970",
        "value": "reduced PV density with altered SWRs",
        "method": "silicon probe LFP, patch-clamp, immunohistochemistry",
        "metric": "PV interneuron density and SWR alteration",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "mice per genotype",
        "scope_region": "hippocampal CA1",
        "study_system": "Cntnap2-/- mouse hippocampus",
        "taxonomic_level": "broad category",
        "scope_population": "all PV interneurons",
        "value_source_sentence": "Cntnap2-/- mice show a reduction in hippocampal PV interneuron density, reduced inhibitory input to CA1 pyramidal cells, and frequency-dependent circuit changes including alterations in gamma oscillations, sharp-wave ripples, and theta-gamma modulation.",
        "experimental_conditions": "Cntnap2 knockout vs controls"
      }
    ],
    "comparison_id": "pv-basket-swr-firing-rate-change",
    "comparison_name": "PV basket cell firing rate changes during sharp-wave ripples: healthy vs disease models",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "PV basket cells show strong SWR activation in healthy hippocampus but selective impairment in AD and ASD models, while other PV subtypes can be spared",
    "homogeneity_check": {
      "caveats": [
        "Different disease models and preparations",
        "Third paper reports all PV cells without subtype distinction"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "true",
      "taxonomic_level_uniform": "false",
      "scope_population_uniform": "false"
    },
    "suggested_plot_type": "grouped bar"
  },
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  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-09",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-09",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-12b8963c5eea",
    "paper:paper-54726517a4fb",
    "paper:paper-78f33d23c109"
  ],
  "section_title": "Brain Region and Layer Context: Beyond Primary Sensory Cortex",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}