Nicotinic vs Muscarinic Contributions to Cortical Desynchronization

{
  "title": "Nicotinic vs Muscarinic Contributions to Cortical Desynchronization",
  "papers": [
    {
      "n": null,
      "doi": "10.1152/jn.00244.2013",
      "value": "both nicotinic and muscarinic",
      "method": "LFP recording + pharmacology",
      "metric": "LFP desynchronization receptor component",
      "n_analyzed": null,
      "CI_or_error": null,
      "text_access": "fulltext",
      "n_definition": "mice under urethane anesthesia",
      "scope_region": "primary somatosensory cortex",
      "study_system": "mouse somatosensory cortex, urethane-anesthetized",
      "taxonomic_level": "species (mouse)",
      "scope_population": "cortical neurons",
      "value_source_sentence": "Desynchronization (1-6 Hz) was localized, extending ≤ 1 mm from the edge of stimulation, and consisted of both nicotinic and muscarinic receptor-mediated components that were inhibited by mecamylamine and atropine, respectively.",
      "experimental_conditions": "ChR2 stimulation of BF cholinergic axons"
    },
    {
      "n": null,
      "doi": "10.1101/2025.06.09.658740",
      "value": "L1 inhibitory neurons (nAChR) and L6 pyramidal neurons (nAChR + mAChR)",
      "method": "in vivo electrophysiology + slice patch-clamp + in situ hybridization",
      "metric": "cholinergic receptor hub location",
      "n_analyzed": null,
      "CI_or_error": null,
      "text_access": "fulltext",
      "n_definition": "mice, acute slices and in vivo",
      "scope_region": "auditory cortex",
      "study_system": "mouse auditory cortex",
      "taxonomic_level": "species (mouse)",
      "scope_population": "L1-L6 neurons",
      "value_source_sentence": "In vivo optogenetic activation of BFCN axons revealed persistent modulation of regular spiking (RS) units in L2-6 but a rapid phasic activation only in L6.",
      "experimental_conditions": "optogenetic activation of BF cholinergic axons"
    },
    {
      "n": null,
      "doi": "10.1101/2023.11.14.567116",
      "value": "high correlation between axon activity and GRAB-ACh fluorescence",
      "method": "simultaneous GCaMP + GRAB-ACh imaging",
      "metric": "ACh dynamics prediction accuracy",
      "n_analyzed": null,
      "CI_or_error": null,
      "text_access": "fulltext",
      "n_definition": "awake behaving mice",
      "scope_region": "cortex (sensory)",
      "study_system": "mouse cortex, in vivo two-photon",
      "taxonomic_level": "species (mouse)",
      "scope_population": "BF cholinergic axons and local ACh levels",
      "value_source_sentence": "GRAB-ACh fluorescence could be accurately predicted from axonal activity alone, providing the first validation that neuromodulator axon activity is a reliable proxy for nearby neuromodulator levels.",
      "experimental_conditions": "spontaneous behavior + locomotion"
    }
  ],
  "comparison_id": "fig_sec4_ach_desync_mechanism",
  "comparison_type": "cross-study mechanism comparison",
  "homogeneity_check": {
    "caveats": [
      "Different cortical regions: somatosensory vs auditory vs general sensory cortex",
      "Different experimental states: urethane anesthesia vs awake behaving",
      "Different metrics: LFP power changes vs EPSP latency vs correlation coefficient",
      "These studies are complementary rather than directly quantitatively comparable"
    ],
    "comparable": false
  },
  "suggested_plot_type": "grouped_bar"
}

[
  "paper:paper-013d8c46dd2d",
  "paper:paper-1db5e36a77e7",
  "paper:paper-ea1cbd1598b3"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}