Version history

{
  "kind": "infographic",
  "prompt": "Nicotinic vs Muscarinic Contributions to Cortical Desynchronization",
  "provider": "other",
  "raw_fields": {
    "title": "Nicotinic vs Muscarinic Contributions to Cortical Desynchronization",
    "papers": [
      {
        "n": null,
        "doi": "10.1152/jn.00244.2013",
        "value": "both nicotinic and muscarinic",
        "method": "LFP recording + pharmacology",
        "metric": "LFP desynchronization receptor component",
        "n_analyzed": null,
        "CI_or_error": null,
        "text_access": "fulltext",
        "n_definition": "mice under urethane anesthesia",
        "scope_region": "primary somatosensory cortex",
        "study_system": "mouse somatosensory cortex, urethane-anesthetized",
        "taxonomic_level": "species (mouse)",
        "scope_population": "cortical neurons",
        "value_source_sentence": "Desynchronization (1-6 Hz) was localized, extending ≤ 1 mm from the edge of stimulation, and consisted of both nicotinic and muscarinic receptor-mediated components that were inhibited by mecamylamine and atropine, respectively.",
        "experimental_conditions": "ChR2 stimulation of BF cholinergic axons"
      },
      {
        "n": null,
        "doi": "10.1101/2025.06.09.658740",
        "value": "L1 inhibitory neurons (nAChR) and L6 pyramidal neurons (nAChR + mAChR)",
        "method": "in vivo electrophysiology + slice patch-clamp + in situ hybridization",
        "metric": "cholinergic receptor hub location",
        "n_analyzed": null,
        "CI_or_error": null,
        "text_access": "fulltext",
        "n_definition": "mice, acute slices and in vivo",
        "scope_region": "auditory cortex",
        "study_system": "mouse auditory cortex",
        "taxonomic_level": "species (mouse)",
        "scope_population": "L1-L6 neurons",
        "value_source_sentence": "In vivo optogenetic activation of BFCN axons revealed persistent modulation of regular spiking (RS) units in L2-6 but a rapid phasic activation only in L6.",
        "experimental_conditions": "optogenetic activation of BF cholinergic axons"
      },
      {
        "n": null,
        "doi": "10.1101/2023.11.14.567116",
        "value": "high correlation between axon activity and GRAB-ACh fluorescence",
        "method": "simultaneous GCaMP + GRAB-ACh imaging",
        "metric": "ACh dynamics prediction accuracy",
        "n_analyzed": null,
        "CI_or_error": null,
        "text_access": "fulltext",
        "n_definition": "awake behaving mice",
        "scope_region": "cortex (sensory)",
        "study_system": "mouse cortex, in vivo two-photon",
        "taxonomic_level": "species (mouse)",
        "scope_population": "BF cholinergic axons and local ACh levels",
        "value_source_sentence": "GRAB-ACh fluorescence could be accurately predicted from axonal activity alone, providing the first validation that neuromodulator axon activity is a reliable proxy for nearby neuromodulator levels.",
        "experimental_conditions": "spontaneous behavior + locomotion"
      }
    ],
    "comparison_id": "fig_sec4_ach_desync_mechanism",
    "comparison_type": "cross-study mechanism comparison",
    "homogeneity_check": {
      "caveats": [
        "Different cortical regions: somatosensory vs auditory vs general sensory cortex",
        "Different experimental states: urethane anesthesia vs awake behaving",
        "Different metrics: LFP power changes vs EPSP latency vs correlation coefficient",
        "These studies are complementary rather than directly quantitatively comparable"
      ],
      "comparable": false
    },
    "suggested_plot_type": "grouped_bar"
  },
  "section_id": "section_04_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation/blob/95db5c630fe54e183d9c452cf826ce502d4a872d/evidence/section_04_evidence.json",
  "target_ref": "wiki_page:computationalreviewneuromodulation-04",
  "review_repo": "ComputationalReviewNeuromodulation",
  "section_ref": "wiki_page:computationalreviewneuromodulation-04",
  "source_path": "evidence/section_04_evidence.json",
  "source_refs": [
    "paper:paper-013d8c46dd2d",
    "paper:paper-1db5e36a77e7",
    "paper:paper-ea1cbd1598b3"
  ],
  "section_title": "Acetylcholine: Brain-Wide Modulation of Attention, Memory, and Cortical State",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-a3dbbaf9b625",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation/blob/95db5c630fe54e183d9c452cf826ce502d4a872d/evidence/section_04_evidence.json",
  "commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}