Short-Term Facilitation at Pyramidal→SST Synapses Across Studies

The facilitating synapse at Pyr→SST connections is a hallmark property distinguishing SST from PV interneurons. Comparing facilitation indices across studies reveals how robust this property is and whether it varies by region, layer, or SST subtype.

{
  "papers": [
    {
      "doi": "10.1523/jneurosci.0949-24.2025",
      "value": "heterogeneous: facilitation, stable, or depression depending on SST subtype",
      "method": "electrophysiology",
      "metric": "facilitation index or paired-pulse ratio",
      "cite_key": "Rachel2025",
      "condition": "mouse, S1 and V1, L2/3 VIP to L4 SST, paired whole-cell recordings",
      "study_system": "mouse, S1 and V1, L2/3 VIP to L4 SST, paired whole-cell recordings",
      "value_source_sentence": "During high-frequency stimulation of both motifs, some connections showed short-term facilitation while others showed a stable response, with a fraction of VIP-to-nMC connections showing short-term depression."
    },
    {
      "doi": "10.3389/fpsyt.2022.1070478",
      "value": null,
      "method": "electrophysiology",
      "metric": "facilitation index or paired-pulse ratio",
      "cite_key": "Chen2023b",
      "condition": "rat, neocortex",
      "study_system": "rat, neocortex",
      "value_source_sentence": null
    },
    {
      "doi": "10.1038/ncomms16032",
      "value": null,
      "method": "electrophysiology",
      "metric": "facilitation index or paired-pulse ratio",
      "cite_key": "Simonnet2017",
      "condition": "mouse",
      "study_system": "mouse",
      "value_source_sentence": null
    },
    {
      "doi": "10.1016/j.neuron.2007.02.012",
      "value": "facilitating; disynaptic inhibition probability >2x direct excitation",
      "method": "paired/triple whole-cell recording",
      "metric": "Pyr→Martinotti facilitating synapse",
      "cite_key": "Silberberg2007",
      "condition": "somatosensory cortex, layer 5",
      "study_system": "rat",
      "value_source_sentence": "Martinotti cells received facilitating synapses from PCs and formed reliable inhibitory synapses onto dendrites of neighboring PCs."
    },
    {
      "doi": "10.1152/jn.00283.2003",
      "value": "facilitating excitatory inputs to LTS cells; depressing inputs to FS cells",
      "method": "paired recording, layer 4",
      "metric": "LTS excitatory input facilitation",
      "cite_key": "Beierlein2003",
      "condition": "somatosensory cortex, thalamocortical slice",
      "study_system": "mouse",
      "value_source_sentence": "LTS cells receive facilitating excitatory inputs while FS cells receive depressing inputs."
    }
  ],
  "comparison_id": "pyr-sst-facilitation-index",
  "comparison_name": "Short-Term Facilitation at Pyramidal→SST Synapses Across Studies",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "The facilitating synapse at Pyr→SST connections is a hallmark property distinguishing SST from PV interneurons. Comparing facilitation indices across studies reveals how robust this property is and whether it varies by region, layer, or SST subtype.",
  "homogeneity_check": {
    "caveats": [
      "Different recording conditions (temperature, solutions), different SST subtypes, different cortical regions"
    ],
    "n_definition": "paired recordings or connections",
    "scope_region": "various cortical areas",
    "scope_population": "pyramidal to SST/Martinotti cell synapses"
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-55e1027b727c",
  "paper:paper-831be156937f",
  "paper:paper-9253e91997c3",
  "paper:paper-a1be7f57e2ee",
  "paper:paper-b2fe37fe47cf"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}