Version history

{
  "kind": "infographic",
  "prompt": "The facilitating synapse at Pyr→SST connections is a hallmark property distinguishing SST from PV interneurons. Comparing facilitation indices across studies reveals how robust this property is and whether it varies by region, layer, or SST subtype.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1523/jneurosci.0949-24.2025",
        "value": "heterogeneous: facilitation, stable, or depression depending on SST subtype",
        "method": "electrophysiology",
        "metric": "facilitation index or paired-pulse ratio",
        "cite_key": "Rachel2025",
        "condition": "mouse, S1 and V1, L2/3 VIP to L4 SST, paired whole-cell recordings",
        "study_system": "mouse, S1 and V1, L2/3 VIP to L4 SST, paired whole-cell recordings",
        "value_source_sentence": "During high-frequency stimulation of both motifs, some connections showed short-term facilitation while others showed a stable response, with a fraction of VIP-to-nMC connections showing short-term depression."
      },
      {
        "doi": "10.3389/fpsyt.2022.1070478",
        "value": null,
        "method": "electrophysiology",
        "metric": "facilitation index or paired-pulse ratio",
        "cite_key": "Chen2023b",
        "condition": "rat, neocortex",
        "study_system": "rat, neocortex",
        "value_source_sentence": null
      },
      {
        "doi": "10.1038/ncomms16032",
        "value": null,
        "method": "electrophysiology",
        "metric": "facilitation index or paired-pulse ratio",
        "cite_key": "Simonnet2017",
        "condition": "mouse",
        "study_system": "mouse",
        "value_source_sentence": null
      },
      {
        "doi": "10.1016/j.neuron.2007.02.012",
        "value": "facilitating; disynaptic inhibition probability >2x direct excitation",
        "method": "paired/triple whole-cell recording",
        "metric": "Pyr→Martinotti facilitating synapse",
        "cite_key": "Silberberg2007",
        "condition": "somatosensory cortex, layer 5",
        "study_system": "rat",
        "value_source_sentence": "Martinotti cells received facilitating synapses from PCs and formed reliable inhibitory synapses onto dendrites of neighboring PCs."
      },
      {
        "doi": "10.1152/jn.00283.2003",
        "value": "facilitating excitatory inputs to LTS cells; depressing inputs to FS cells",
        "method": "paired recording, layer 4",
        "metric": "LTS excitatory input facilitation",
        "cite_key": "Beierlein2003",
        "condition": "somatosensory cortex, thalamocortical slice",
        "study_system": "mouse",
        "value_source_sentence": "LTS cells receive facilitating excitatory inputs while FS cells receive depressing inputs."
      }
    ],
    "comparison_id": "pyr-sst-facilitation-index",
    "comparison_name": "Short-Term Facilitation at Pyramidal→SST Synapses Across Studies",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "The facilitating synapse at Pyr→SST connections is a hallmark property distinguishing SST from PV interneurons. Comparing facilitation indices across studies reveals how robust this property is and whether it varies by region, layer, or SST subtype.",
    "homogeneity_check": {
      "caveats": [
        "Different recording conditions (temperature, solutions), different SST subtypes, different cortical regions"
      ],
      "n_definition": "paired recordings or connections",
      "scope_region": "various cortical areas",
      "scope_population": "pyramidal to SST/Martinotti cell synapses"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_06_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_06_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-06",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-06",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-55e1027b727c",
    "paper:paper-831be156937f",
    "paper:paper-9253e91997c3",
    "paper:paper-a1be7f57e2ee",
    "paper:paper-b2fe37fe47cf"
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_06_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}