{
"papers": [
{
"doi": "10.1101/2024.07.09.602783",
"value": "NMDAR-dependent nonlinear integration in SST-INs vs passive integration in PV-INs",
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Morabito2024",
"condition": "mouse, visual cortex, in vitro and in vivo (awake), two-photon imaging, electrophysiology",
"study_system": "mouse, visual cortex, in vitro and in vivo (awake), two-photon imaging, electrophysiology",
"value_source_sentence": "We found that somatostatin (SST)-INs exhibit NMDAR-dependent dendritic integration and uniform synapse density along the dendritic tree. In contrast, dendrites of parvalbumin (PV)-INs exhibit passive synaptic integration coupled with proximally enriched synaptic distributions."
},
{
"doi": "10.1523/eneuro.0441-21.2022",
"value": "18%",
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Fernandez2022",
"condition": "mouse, neocortex, visual cortex, in vitro",
"study_system": "mouse, neocortex, visual cortex, in vitro",
"value_source_sentence": "Using fluorescence-guided paired recordings in mouse brain slices from interneurons and excitatory cells in layer 2/3 mEC, we found that, unlike neocortical measures, Sst<sup>+</sup> cells inhibit each other, albeit with a lower probability than Pvalb<sup>+</sup> cells (18% vs 36% for unidirectional connections)."
},
{
"doi": "10.3389/fpsyt.2022.1070478",
"value": null,
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Chen2023b",
"condition": "rat, neocortex",
"study_system": "rat, neocortex",
"value_source_sentence": null
},
{
"doi": "10.1038/s41598-024-70278-w",
"value": null,
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Wiera2024",
"condition": "rat, hippocampus",
"study_system": "rat, hippocampus",
"value_source_sentence": null
},
{
"doi": "10.1523/jneurosci.1963-24.2025",
"value": "2",
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Cole2025",
"condition": "mouse, rat, neocortex, prefrontal cortex, in vitro",
"study_system": "mouse, rat, neocortex, prefrontal cortex, in vitro",
"value_source_sentence": "We show that across these receptor systems, DOR activation is more effective at suppressing spontaneous inhibitory transmission in layer 2/3 of the prelimbic PFC, while MOR causes a greater acute suppression of electrically evoked GABA release, and KOR plays a minor role in inhibitory transmission."
},
{
"doi": "10.1007/s00702-025-02949-5",
"value": "4 ",
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Kanigowski2025",
"condition": "mouse, neocortex, barrel cortex, somatosensory cortex, in vitro",
"study_system": "mouse, neocortex, barrel cortex, somatosensory cortex, in vitro",
"value_source_sentence": "These findings suggest that enhanced inhibition by SST-INs and PV-INs may improve information processing and memory coding in L4 of the barrel cortex."
},
{
"doi": "10.1113/jp286439",
"value": "68%",
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Bogaj2025",
"condition": "mouse, rat, neocortex, somatosensory cortex, in vitro",
"study_system": "mouse, rat, neocortex, somatosensory cortex, in vitro",
"value_source_sentence": "Utilizing machine learning algorithms (hierarchical clustering and principal component analysis), we revealed that one VIP-IN cluster (about 68% of all VIP-INs) was sensitive to GABAbR activation."
},
{
"doi": "10.1007/s00424-024-02923-2",
"value": "80%",
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Mao2024",
"condition": "rat, neocortex",
"study_system": "rat, neocortex",
"value_source_sentence": "Since more than a century, neuroscientists have distinguished excitatory (glutamatergic) neurons with long-distance projections from inhibitory (GABAergic) neurons with local projections and established layer-dependent schemes for the ~ 80% excitatory (principal) cells as well as the ~ 20% inhibitory neurons."
},
{
"doi": "10.1007/s43440-024-00674-6",
"value": null,
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Siwiec2024",
"condition": "mouse, hippocampus, in vitro",
"study_system": "mouse, hippocampus, in vitro",
"value_source_sentence": null
},
{
"doi": "10.1038/s41593-025-01888-4",
"value": null,
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "DelRosario2025",
"condition": "mouse, rat, neocortex, visual cortex",
"study_system": "mouse, rat, neocortex, visual cortex",
"value_source_sentence": null
},
{
"doi": "10.1016/j.celrep.2022.111757",
"value": null,
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Royero2022",
"condition": "rat, in vitro",
"study_system": "rat, in vitro",
"value_source_sentence": null
},
{
"doi": "10.1101/2025.07.24.666602",
"value": "1 ",
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Hinojosa2025",
"condition": "mouse, rat, neocortex, visual cortex",
"study_system": "mouse, rat, neocortex, visual cortex",
"value_source_sentence": "The apparently paradoxical combination of increased PC gain but decreased synaptic strength is consistent with a state-dependent gating mechanism that boosts signals leaving V1 while simultaneously preventing disruption of the local excitatory-inhibitory balance required for stable computation."
},
{
"doi": "10.1016/j.celrep.2024.114898",
"value": null,
"method": "electrophysiology/optogenetics",
"metric": "PV↔SST connectivity/inhibition",
"cite_key": "Jiang2024a",
"condition": "rat, hippocampus",
"study_system": "rat, hippocampus",
"value_source_sentence": null
}
],
"comparison_id": "pv-sst-mutual-inhibition",
"comparison_name": "PV↔SST Mutual Inhibition: Strength and Asymmetry",
"comparison_type": "cross-study conflict",
"what_it_reveals": "The PV-SST mutual inhibition is a critical cortical microcircuit motif. Cross-study comparison reveals the asymmetry of this connection (SST→PV typically stronger than PV→SST) and how it varies across conditions.",
"homogeneity_check": {
"caveats": [
"Different cortical areas, ages, and recording conditions may affect comparison"
],
"n_definition": "paired recordings",
"scope_region": "neocortex, various areas",
"scope_population": "PV and SST interneurons"
},
"suggested_plot_type": "forest plot"
}