Effects of Hippocampal SST Interneuron Manipulation on Memory Tasks

SST interneuron manipulations affect multiple memory domains — fear conditioning, spatial memory, object location, and reward learning — but through potentially different mechanisms (dendritic gating, mTORC1-dependent plasticity, disinhibition). This comparison reveals the breadth of SST contributions to hippocampal memory and highlights the need to distinguish mechanism from phenotype.

{
  "papers": [
    {
      "doi": "10.1126/science.1247485",
      "value": "SST silencing impairs contextual fear conditioning",
      "method": "optogenetics",
      "metric": "Fear memory formation",
      "cite_key": "LovettBarron2014",
      "condition": "contextual fear conditioning",
      "study_system": "mouse",
      "value_source_sentence": "Dendritic inhibition in the hippocampus supports fear learning."
    },
    {
      "doi": "10.1371/journal.pbio.3002154",
      "value": "SST re-inhibition recalls fear memory; SST inhibition impairs recall",
      "method": "optogenetics",
      "metric": "Fear memory recall",
      "cite_key": "Zicho2023",
      "condition": "fear memory recall",
      "study_system": "mouse",
      "value_source_sentence": "Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory."
    },
    {
      "doi": "10.1523/jneurosci.0728-19.2019",
      "value": "Bidirectional: mTORC1 upregulation enhances, downregulation impairs memory",
      "method": "conditional knockout",
      "metric": "Contextual fear and spatial memory consolidation",
      "cite_key": "Artinian2019",
      "condition": "contextual fear + Morris water maze",
      "study_system": "mouse",
      "value_source_sentence": "upregulation and downregulation of SOM-IN mTORC1 activity bidirectionally regulates contextual fear and spatial memory consolidation."
    },
    {
      "doi": "10.1186/s13041-022-00988-7",
      "value": "SST chemogenetic silencing impairs spatial memory",
      "method": "chemogenetics (DREADD)",
      "metric": "Object location memory",
      "cite_key": "Honore2022",
      "condition": "object location task",
      "study_system": "mouse",
      "value_source_sentence": "Object location learning in mice requires hippocampal somatostatin interneuron-dependent long-term synaptic plasticity."
    },
    {
      "doi": "10.1016/j.celrep.2024.114880",
      "value": "Ventral hippocampal SST interneurons govern fear extinction",
      "method": "optogenetics/chemogenetics",
      "metric": "Fear extinction and relapse",
      "cite_key": "Lacagnina2024",
      "condition": "fear extinction",
      "study_system": "mouse",
      "value_source_sentence": "Ventral hippocampal interneurons govern extinction and relapse of contextual fear."
    }
  ],
  "comparison_id": "sst-memory-manipulation-effects",
  "comparison_name": "Effects of Hippocampal SST Interneuron Manipulation on Memory Tasks",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "SST interneuron manipulations affect multiple memory domains — fear conditioning, spatial memory, object location, and reward learning — but through potentially different mechanisms (dendritic gating, mTORC1-dependent plasticity, disinhibition). This comparison reveals the breadth of SST contributions to hippocampal memory and highlights the need to distinguish mechanism from phenotype.",
  "homogeneity_check": {
    "caveats": "Different behavioral tasks, manipulation methods (optogenetics vs chemogenetics vs genetic), and hippocampal subregions. All in mouse but targeting different SST populations (all SST+ vs specific subtypes).",
    "comparable": true,
    "n_definition": "varies by study — behavioral animal n",
    "scope_region": "hippocampus (various subregions)",
    "taxonomic_level": "broad SST class",
    "scope_population": "SST-Cre expressing neurons"
  },
  "suggested_plot_type": "forest plot"
}

[
  "paper:paper-0c759b28e7ed",
  "paper:paper-1470e4598e32",
  "paper:paper-83a127a233c8",
  "paper:paper-e9f2f58c35e6",
  "paper:paper-f2511e36008f"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}