Version history

{
  "kind": "infographic",
  "prompt": "SST interneuron manipulations affect multiple memory domains — fear conditioning, spatial memory, object location, and reward learning — but through potentially different mechanisms (dendritic gating, mTORC1-dependent plasticity, disinhibition). This comparison reveals the breadth of SST contributions to hippocampal memory and highlights the need to distinguish mechanism from phenotype.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1126/science.1247485",
        "value": "SST silencing impairs contextual fear conditioning",
        "method": "optogenetics",
        "metric": "Fear memory formation",
        "cite_key": "LovettBarron2014",
        "condition": "contextual fear conditioning",
        "study_system": "mouse",
        "value_source_sentence": "Dendritic inhibition in the hippocampus supports fear learning."
      },
      {
        "doi": "10.1371/journal.pbio.3002154",
        "value": "SST re-inhibition recalls fear memory; SST inhibition impairs recall",
        "method": "optogenetics",
        "metric": "Fear memory recall",
        "cite_key": "Zicho2023",
        "condition": "fear memory recall",
        "study_system": "mouse",
        "value_source_sentence": "Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory."
      },
      {
        "doi": "10.1523/jneurosci.0728-19.2019",
        "value": "Bidirectional: mTORC1 upregulation enhances, downregulation impairs memory",
        "method": "conditional knockout",
        "metric": "Contextual fear and spatial memory consolidation",
        "cite_key": "Artinian2019",
        "condition": "contextual fear + Morris water maze",
        "study_system": "mouse",
        "value_source_sentence": "upregulation and downregulation of SOM-IN mTORC1 activity bidirectionally regulates contextual fear and spatial memory consolidation."
      },
      {
        "doi": "10.1186/s13041-022-00988-7",
        "value": "SST chemogenetic silencing impairs spatial memory",
        "method": "chemogenetics (DREADD)",
        "metric": "Object location memory",
        "cite_key": "Honore2022",
        "condition": "object location task",
        "study_system": "mouse",
        "value_source_sentence": "Object location learning in mice requires hippocampal somatostatin interneuron-dependent long-term synaptic plasticity."
      },
      {
        "doi": "10.1016/j.celrep.2024.114880",
        "value": "Ventral hippocampal SST interneurons govern fear extinction",
        "method": "optogenetics/chemogenetics",
        "metric": "Fear extinction and relapse",
        "cite_key": "Lacagnina2024",
        "condition": "fear extinction",
        "study_system": "mouse",
        "value_source_sentence": "Ventral hippocampal interneurons govern extinction and relapse of contextual fear."
      }
    ],
    "comparison_id": "sst-memory-manipulation-effects",
    "comparison_name": "Effects of Hippocampal SST Interneuron Manipulation on Memory Tasks",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "SST interneuron manipulations affect multiple memory domains — fear conditioning, spatial memory, object location, and reward learning — but through potentially different mechanisms (dendritic gating, mTORC1-dependent plasticity, disinhibition). This comparison reveals the breadth of SST contributions to hippocampal memory and highlights the need to distinguish mechanism from phenotype.",
    "homogeneity_check": {
      "caveats": "Different behavioral tasks, manipulation methods (optogenetics vs chemogenetics vs genetic), and hippocampal subregions. All in mouse but targeting different SST populations (all SST+ vs specific subtypes).",
      "comparable": true,
      "n_definition": "varies by study — behavioral animal n",
      "scope_region": "hippocampus (various subregions)",
      "taxonomic_level": "broad SST class",
      "scope_population": "SST-Cre expressing neurons"
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_09_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_09_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-09",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-09",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-0c759b28e7ed",
    "paper:paper-1470e4598e32",
    "paper:paper-83a127a233c8",
    "paper:paper-e9f2f58c35e6",
    "paper:paper-f2511e36008f"
  ],
  "section_title": "Hippocampal SST Interneurons",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_09_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}