{
"papers": [
{
"doi": "10.1159/000549093",
"value": "frequency: 000 Hz",
"method": "whole-cell patch-clamp / pharmacology",
"metric": "neuromodulatory response",
"cite_key": "Kallo2025",
"condition": "",
"study_system": "mouse, cortex, in vivo",
"value_source_sentence": "MUA was detected in a band-pass-filtered signal between 400 and 4,000 Hz, in which all negative events exceeding 3.5 standard deviations (SDs) below the mean (calculated over the entire trace) were considered as spikes (>99.9% confidence) [37].The onset of the evoked response was calculated as a tim"
},
{
"doi": "10.7554/elife.66960",
"value": "frequency: 1–10 Hz",
"method": "whole-cell patch-clamp / pharmacology",
"metric": "neuromodulatory response",
"cite_key": "deFilippo2021",
"condition": "",
"study_system": "mouse, cortex, in vivo",
"value_source_sentence": "In agreement with this line of thought, electrical and optogenetic stimulation of the Raphe nuclei reduce low frequency (1–10 Hz) power in the cortex, implying a reduction in neuronal synchronization at these frequencies (Puig et al., 2010; Grandjean et al., 2019)."
},
{
"doi": "10.7554/elife.97100",
"value": "current: 200 pA",
"method": "whole-cell patch-clamp / pharmacology",
"metric": "neuromodulatory response",
"cite_key": "Francavilla2025",
"condition": "",
"study_system": "mouse, cortex, in vivo",
"value_source_sentence": "(b, bottom) Post hoc immunohistochemical validation showing immunopositivity for SST.Figure 1—figure supplement 2.Blockade of voltage-dependent Na+ channels by TTX abolished APs in PV+ cells from adult primary auditory cortex.(a) Representative voltage responses of a PV+ cell at threshold current (+"
},
{
"doi": "10.1073/pnas.2410828121",
"value": "time: 250 ms",
"method": "whole-cell patch-clamp / pharmacology",
"metric": "neuromodulatory response",
"cite_key": "Duhne2024",
"condition": "",
"study_system": "rat, in vitro",
"value_source_sentence": "TANs typically show a brief (~150 to 250 ms) pause in firing after salient cues, especially cues that evoke behavioral responses."
},
{
"doi": "10.3390/ijms26157253",
"value": "voltage: 0 mV",
"method": "whole-cell patch-clamp / pharmacology",
"metric": "neuromodulatory response",
"cite_key": "Kandilakis2025",
"condition": "",
"study_system": "rat, hippocampus, in vivo",
"value_source_sentence": "In dentate gyrus (DG) basket cells and hippocampal interneurons, 5-HT3R-mediated currents exhibit voltage- and Ca2+-dependent behavior with a reversal potential near 0 mV."
}
],
"comparison_id": "sst-neuromodulatory-responses",
"comparison_name": "Neuromodulatory Responses of SST Interneurons Across Studies",
"comparison_type": "convergent evidence",
"what_it_reveals": "Compares the magnitude and direction of responses to different neuromodulators (ACh, 5-HT, DA, NE) across SST subtypes. Reveals whether neuromodulatory sensitivity is a conserved SST property or varies by subtype.",
"homogeneity_check": {
"caveats": [
"Different concentrations and application methods",
"Different receptor subtypes targeted",
"Bath vs local application",
"Different species and brain regions"
],
"comparable": false
},
"suggested_plot_type": "grouped bar"
}