Version history

{
  "kind": "infographic",
  "prompt": "Compares the magnitude and direction of responses to different neuromodulators (ACh, 5-HT, DA, NE) across SST subtypes. Reveals whether neuromodulatory sensitivity is a conserved SST property or varies by subtype.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1159/000549093",
        "value": "frequency: 000 Hz",
        "method": "whole-cell patch-clamp / pharmacology",
        "metric": "neuromodulatory response",
        "cite_key": "Kallo2025",
        "condition": "",
        "study_system": "mouse, cortex, in vivo",
        "value_source_sentence": "MUA was detected in a band-pass-filtered signal between 400 and 4,000 Hz, in which all negative events exceeding 3.5 standard deviations (SDs) below the mean (calculated over the entire trace) were considered as spikes (>99.9% confidence) [37].The onset of the evoked response was calculated as a tim"
      },
      {
        "doi": "10.7554/elife.66960",
        "value": "frequency: 1–10 Hz",
        "method": "whole-cell patch-clamp / pharmacology",
        "metric": "neuromodulatory response",
        "cite_key": "deFilippo2021",
        "condition": "",
        "study_system": "mouse, cortex, in vivo",
        "value_source_sentence": "In agreement with this line of thought, electrical and optogenetic stimulation of the Raphe nuclei reduce low frequency (1–10 Hz) power in the cortex, implying a reduction in neuronal synchronization at these frequencies (Puig et al., 2010; Grandjean et al., 2019)."
      },
      {
        "doi": "10.7554/elife.97100",
        "value": "current: 200 pA",
        "method": "whole-cell patch-clamp / pharmacology",
        "metric": "neuromodulatory response",
        "cite_key": "Francavilla2025",
        "condition": "",
        "study_system": "mouse, cortex, in vivo",
        "value_source_sentence": "(b, bottom) Post hoc immunohistochemical validation showing immunopositivity for SST.Figure 1—figure supplement 2.Blockade of voltage-dependent Na+ channels by TTX abolished APs in PV+ cells from adult primary auditory cortex.(a) Representative voltage responses of a PV+ cell at threshold current (+"
      },
      {
        "doi": "10.1073/pnas.2410828121",
        "value": "time: 250 ms",
        "method": "whole-cell patch-clamp / pharmacology",
        "metric": "neuromodulatory response",
        "cite_key": "Duhne2024",
        "condition": "",
        "study_system": "rat, in vitro",
        "value_source_sentence": "TANs typically show a brief (~150 to 250 ms) pause in firing after salient cues, especially cues that evoke behavioral responses."
      },
      {
        "doi": "10.3390/ijms26157253",
        "value": "voltage: 0 mV",
        "method": "whole-cell patch-clamp / pharmacology",
        "metric": "neuromodulatory response",
        "cite_key": "Kandilakis2025",
        "condition": "",
        "study_system": "rat, hippocampus, in vivo",
        "value_source_sentence": "In dentate gyrus (DG) basket cells and hippocampal interneurons, 5-HT3R-mediated currents exhibit voltage- and Ca2+-dependent behavior with a reversal potential near 0 mV."
      }
    ],
    "comparison_id": "sst-neuromodulatory-responses",
    "comparison_name": "Neuromodulatory Responses of SST Interneurons Across Studies",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "Compares the magnitude and direction of responses to different neuromodulators (ACh, 5-HT, DA, NE) across SST subtypes. Reveals whether neuromodulatory sensitivity is a conserved SST property or varies by subtype.",
    "homogeneity_check": {
      "caveats": [
        "Different concentrations and application methods",
        "Different receptor subtypes targeted",
        "Bath vs local application",
        "Different species and brain regions"
      ],
      "comparable": false
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_05_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-05",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-05",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-44feaff02c05",
    "paper:paper-50abfd885e9f",
    "paper:41e3ffd9-f0ba-49ca-875f-11724b72cd8d",
    "paper:paper-8ca0085288d3",
    "paper:paper-9469f226e9df"
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_05_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}