{
"axis": {
"x": "Genotype",
"y": "Resting intracellular [Ca²⁺] (nM)"
},
"notes": "Alzheimer's disease models exhibit nearly doubled resting astrocyte Ca²⁺, aberrant long-range calcium waves, and downstream pathological cascades (complement, ApoE aggregation) that are ameliorated by targeting astrocyte-associated pathways such as C3.",
"theme": "Astrocyte calcium dysregulation in Alzheimer's disease models",
"papers": [
"10.1126/science.1169096",
"10.1126/scitranslmed.aaf6295",
"10.1186/s13024-022-00566-4"
],
"datapoints": [
{
"doi": "10.1126/science.1169096",
"group": "Wild-type mouse cortical astrocytes / APPswe/PS1d9 transgenic mouse cortical astrocytes / AD model – intercellular Ca²⁺ wave spread distance (plaque-bearing only) / AD model – correlated astrocyte activity distance",
"units": "nM",
"value": 81,
"values": {
"Wild-type mouse cortical astrocytes": 81,
"APPswe/PS1d9 transgenic mouse cortical astrocytes": 149,
"AD model – correlated astrocyte activity distance": 200,
"AD model – intercellular Ca²⁺ wave spread distance (plaque-bearing only)": 200
},
"source_sentence": "Furthermore, rare intercellular calcium waves were observed, but only in mice with amyloid-β plaques, originating near plaques and spreading radially at least 200 µm.",
"value_source_sentence": "Furthermore, rare intercellular calcium waves were observed, but only in mice with amyloid-β plaques, originating near plaques and spreading radially at least 200 µm."
},
{
"doi": "10.1126/scitranslmed.aaf6295",
"group": "APP/PS1;C3 KO – CA3 neuron loss rescued (vs 40% loss in APP/PS1)",
"units": "% neuron loss rescued",
"value": 40,
"values": {
"APP/PS1;C3 KO – CA3 neuron loss rescued (vs 40% loss in APP/PS1)": 40
},
"source_sentence": "A stronger (40%) reduction in CA3 neurons was seen from P30 to 16 months of age in APP/PS1 mice ( p < 0.",
"value_source_sentence": "A stronger (40%) reduction in CA3 neurons was seen from P30 to 16 months of age in APP/PS1 mice ( p < 0."
},
{
"doi": "10.1186/s13024-022-00566-4",
"group": "APOE4/4 AD – ApoE particle size vs APOE3/3",
"units": "fold larger",
"value": 2,
"values": {
"APOE4/4 AD – ApoE particle size vs APOE3/3": 2
},
"source_sentence": "For instance, a study comparing apoE particle size from temporal lobe brain homogenates of AD and control patients by size-exclusion chromatography found that apoE particles in APOE4/4 patients were twice as big as those from APOE3/3 AD patients and APOE3/3 control subjects [ 125 ].",
"value_source_sentence": "For instance, a study comparing apoE particle size from temporal lobe brain homogenates of AD and control patients by size-exclusion chromatography found that apoE particles in APOE4/4 patients were twice as big as those from APOE3/3 AD patients and APOE3/3 control subjects [ 125 ]."
}
],
"comparison_id": "alzheimer_astrocyte_calcium"
}