Version history

{
  "kind": "infographic",
  "prompt": "Species Differences and Human Disease figure 3",
  "provider": "other",
  "raw_fields": {
    "axis": {
      "x": "Genotype",
      "y": "Resting intracellular [Ca²⁺] (nM)"
    },
    "notes": "Alzheimer's disease models exhibit nearly doubled resting astrocyte Ca²⁺, aberrant long-range calcium waves, and downstream pathological cascades (complement, ApoE aggregation) that are ameliorated by targeting astrocyte-associated pathways such as C3.",
    "theme": "Astrocyte calcium dysregulation in Alzheimer's disease models",
    "papers": [
      "10.1126/science.1169096",
      "10.1126/scitranslmed.aaf6295",
      "10.1186/s13024-022-00566-4"
    ],
    "datapoints": [
      {
        "doi": "10.1126/science.1169096",
        "group": "Wild-type mouse cortical astrocytes / APPswe/PS1d9 transgenic mouse cortical astrocytes / AD model – intercellular Ca²⁺ wave spread distance (plaque-bearing only) / AD model – correlated astrocyte activity distance",
        "units": "nM",
        "value": 81,
        "values": {
          "Wild-type mouse cortical astrocytes": 81,
          "APPswe/PS1d9 transgenic mouse cortical astrocytes": 149,
          "AD model – correlated astrocyte activity distance": 200,
          "AD model – intercellular Ca²⁺ wave spread distance (plaque-bearing only)": 200
        },
        "source_sentence": "Furthermore, rare intercellular calcium waves were observed, but only in mice with amyloid-β plaques, originating near plaques and spreading radially at least 200 µm.",
        "value_source_sentence": "Furthermore, rare intercellular calcium waves were observed, but only in mice with amyloid-β plaques, originating near plaques and spreading radially at least 200 µm."
      },
      {
        "doi": "10.1126/scitranslmed.aaf6295",
        "group": "APP/PS1;C3 KO – CA3 neuron loss rescued (vs 40% loss in APP/PS1)",
        "units": "% neuron loss rescued",
        "value": 40,
        "values": {
          "APP/PS1;C3 KO – CA3 neuron loss rescued (vs 40% loss in APP/PS1)": 40
        },
        "source_sentence": "A stronger (40%) reduction in CA3 neurons was seen from P30 to 16 months of age in APP/PS1 mice ( p < 0.",
        "value_source_sentence": "A stronger (40%) reduction in CA3 neurons was seen from P30 to 16 months of age in APP/PS1 mice ( p < 0."
      },
      {
        "doi": "10.1186/s13024-022-00566-4",
        "group": "APOE4/4 AD – ApoE particle size vs APOE3/3",
        "units": "fold larger",
        "value": 2,
        "values": {
          "APOE4/4 AD – ApoE particle size vs APOE3/3": 2
        },
        "source_sentence": "For instance, a study comparing apoE particle size from temporal lobe brain homogenates of AD and control patients by size-exclusion chromatography found that apoE particles in APOE4/4 patients were twice as big as those from APOE3/3 AD patients and APOE3/3 control subjects [ 125 ].",
        "value_source_sentence": "For instance, a study comparing apoE particle size from temporal lobe brain homogenates of AD and control patients by size-exclusion chromatography found that apoE particles in APOE4/4 patients were twice as big as those from APOE3/3 AD patients and APOE3/3 control subjects [ 125 ]."
      }
    ],
    "comparison_id": "alzheimer_astrocyte_calcium"
  },
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    "paper:paper-d74c3cfc15b9",
    "paper:paper-290ca86a608f",
    "paper:paper-a83e8d05b731"
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  "section_title": "Species Differences and Human Disease",
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      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes/blob/1a55da0634a3bc04e5688792ed12141ce271d28e/evidence/section_12_evidence_package.json",
  "commit_sha": "1a55da0634a3bc04e5688792ed12141ce271d28e",
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