SST Neuron Activity Changes During Locomotion Across Cortical Areas

{
  "papers": [
    {
      "doi": "10.7554/elife.05558",
      "value": "SST neurons suppressed during locomotion in V1",
      "method": "calcium imaging",
      "metric": "SST neuron activity change during locomotion",
      "cite_key": "Fu2015",
      "condition": "V1, locomotion vs stationary",
      "study_system": "mouse",
      "value_source_sentence": "A cortical disinhibitory circuit for enhancing adult plasticity."
    },
    {
      "doi": "10.1126/science.aag2599",
      "value": "Layer-specific reduction of SST-mediated inhibition during active wakefulness",
      "method": "two-photon imaging",
      "metric": "SST-mediated dendritic inhibition during active wakefulness",
      "cite_key": "Munoz2017",
      "condition": "S1, active vs quiet wakefulness",
      "study_system": "mouse",
      "value_source_sentence": "Layer-specific modulation of neocortical dendritic inhibition during active wakefulness."
    },
    {
      "doi": "10.1038/nature12176",
      "value": "SST neurons in PFC show choice-specific not locomotion-related modulation",
      "method": "electrophysiology with optogenetic tagging",
      "metric": "SST neuron behavioral correlates in PFC",
      "cite_key": "Kvitsiani2013",
      "condition": "PFC, foraging task",
      "study_system": "mouse",
      "value_source_sentence": "Distinct behavioural and network correlates of two interneuron types in prefrontal cortex."
    },
    {
      "doi": "10.1523/jneurosci.1076-17.2017",
      "value": "Dedicated hippocampal inhibitory networks for locomotion and immobility",
      "method": "electrophysiology",
      "metric": "SST neuron activity during locomotion vs immobility",
      "cite_key": "Arriaga2017",
      "condition": "hippocampus, locomotion vs immobility",
      "study_system": "mouse",
      "value_source_sentence": "Dedicated Hippocampal Inhibitory Networks for Locomotion and Immobility."
    }
  ],
  "comparison_id": "sst-locomotion-suppression-across-areas",
  "comparison_name": "SST Neuron Activity Changes During Locomotion Across Cortical Areas",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "Whether SST suppression during locomotion is a universal cortical motif or area-specific. Visual cortex shows robust suppression but generality is uncertain.",
  "homogeneity_check": {
    "caveats": [
      "Different brain areas (V1, S1, PFC, hippocampus) with different circuit architectures",
      "Different recording methods across studies",
      "Different behavioral paradigms and definitions of locomotion"
    ],
    "comparable": false
  },
  "suggested_plot_type": "grouped bar"
}

[
  "paper:paper-3f5bd9932217",
  "paper:paper-53b307da1da8",
  "paper:paper-f22eb24f5525",
  "paper:paper-f8c7cbda4ea7"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}