Version history

{
  "kind": "infographic",
  "prompt": "Whether SST suppression during locomotion is a universal cortical motif or area-specific. Visual cortex shows robust suppression but generality is uncertain.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.7554/elife.05558",
        "value": "SST neurons suppressed during locomotion in V1",
        "method": "calcium imaging",
        "metric": "SST neuron activity change during locomotion",
        "cite_key": "Fu2015",
        "condition": "V1, locomotion vs stationary",
        "study_system": "mouse",
        "value_source_sentence": "A cortical disinhibitory circuit for enhancing adult plasticity."
      },
      {
        "doi": "10.1126/science.aag2599",
        "value": "Layer-specific reduction of SST-mediated inhibition during active wakefulness",
        "method": "two-photon imaging",
        "metric": "SST-mediated dendritic inhibition during active wakefulness",
        "cite_key": "Munoz2017",
        "condition": "S1, active vs quiet wakefulness",
        "study_system": "mouse",
        "value_source_sentence": "Layer-specific modulation of neocortical dendritic inhibition during active wakefulness."
      },
      {
        "doi": "10.1038/nature12176",
        "value": "SST neurons in PFC show choice-specific not locomotion-related modulation",
        "method": "electrophysiology with optogenetic tagging",
        "metric": "SST neuron behavioral correlates in PFC",
        "cite_key": "Kvitsiani2013",
        "condition": "PFC, foraging task",
        "study_system": "mouse",
        "value_source_sentence": "Distinct behavioural and network correlates of two interneuron types in prefrontal cortex."
      },
      {
        "doi": "10.1523/jneurosci.1076-17.2017",
        "value": "Dedicated hippocampal inhibitory networks for locomotion and immobility",
        "method": "electrophysiology",
        "metric": "SST neuron activity during locomotion vs immobility",
        "cite_key": "Arriaga2017",
        "condition": "hippocampus, locomotion vs immobility",
        "study_system": "mouse",
        "value_source_sentence": "Dedicated Hippocampal Inhibitory Networks for Locomotion and Immobility."
      }
    ],
    "comparison_id": "sst-locomotion-suppression-across-areas",
    "comparison_name": "SST Neuron Activity Changes During Locomotion Across Cortical Areas",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "Whether SST suppression during locomotion is a universal cortical motif or area-specific. Visual cortex shows robust suppression but generality is uncertain.",
    "homogeneity_check": {
      "caveats": [
        "Different brain areas (V1, S1, PFC, hippocampus) with different circuit architectures",
        "Different recording methods across studies",
        "Different behavioral paradigms and definitions of locomotion"
      ],
      "comparable": false
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-08",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-08",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-3f5bd9932217",
    "paper:paper-53b307da1da8",
    "paper:paper-f22eb24f5525",
    "paper:paper-f8c7cbda4ea7"
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}