Neuromodulatory changes during brain state transitions (wake-NREM-REM)

{
  "title": "Neuromodulatory changes during brain state transitions (wake-NREM-REM)",
  "papers": [
    {
      "n": 16,
      "doi": "10.1126/science.adq5233",
      "value": "200 nM",
      "n_analyzed": 16,
      "n_definition": "varies by study",
      "scope_region": "brain-wide / specific regions per study",
      "study_system": "computational model",
      "scope_population": "computational model",
      "value_source_sentence": "( H ) Experimental schematic:  in vivo  widefield imaging during chemogenetic activation of  Tg(gfap:rTRPV1-eGFP)  fish with 200 nM capsaicin in the presence of a neural activity blocker (170 mg/L MS-"
    },
    {
      "n": null,
      "doi": "10.1016/j.neuron.2025.02.004",
      "value": "50%",
      "n_analyzed": null,
      "n_definition": "varies by study",
      "scope_region": "brain-wide / specific regions per study",
      "study_system": "rat",
      "scope_population": "rat",
      "value_source_sentence": "N1 is the transitional phase between wakefulness and sleep, occurring when more than 50% of alpha waves in electroencephalogram (EEG) recordings are replaced with low-amplitude, mixed-frequency activi"
    },
    {
      "n": 29,
      "doi": "10.1126/sciadv.adi0643",
      "value": "100 μM",
      "n_analyzed": 29,
      "n_definition": "varies by study",
      "scope_region": "brain-wide / specific regions per study",
      "study_system": "rat",
      "scope_population": "rat",
      "value_source_sentence": "0  sensor under baseline and with 100 μM ACh."
    },
    {
      "n": null,
      "doi": "10.3390/ijms262110766",
      "value": "20%",
      "n_analyzed": null,
      "n_definition": "varies by study",
      "scope_region": "brain-wide / specific regions per study",
      "study_system": "rat",
      "scope_population": "rat",
      "value_source_sentence": "provided direct electrophysiological evidence that cortical pyramidal neurons and hippocampal granule cells exhibit statistically significant daily fluctuations in membrane capacitance, with amplitude"
    },
    {
      "n": null,
      "doi": "10.3389/fnins.2024.1426189",
      "value": "4 Hz",
      "n_analyzed": null,
      "n_definition": "varies by study",
      "scope_region": "brain-wide / specific regions per study",
      "study_system": "mouse",
      "scope_population": "mouse",
      "value_source_sentence": "5–4 Hz oscillatory activity which occur within NREM sleep as the result of the simultaneous activation and subsequent inactivation of large neural populations."
    },
    {
      "n": null,
      "doi": "10.3389/fncel.2025.1606265",
      "value": "4 Hz",
      "n_analyzed": null,
      "n_definition": "varies by study",
      "scope_region": "brain-wide / specific regions per study",
      "study_system": "rat",
      "scope_population": "rat",
      "value_source_sentence": "5–4 Hz ( Kim et al."
    },
    {
      "n": null,
      "doi": "10.1371/journal.pcbi.1012262",
      "value": "50%",
      "n_analyzed": null,
      "n_definition": "varies by study",
      "scope_region": "brain-wide / specific regions per study",
      "study_system": "rat",
      "scope_population": "rat",
      "value_source_sentence": "Notably, the number of thalamo-cortical outgoing axons is approximately one-tenth of the number of cortico-thalamic incoming axons [ 4 ,  5 ], and the cortex is the major source of synapses within the"
    },
    {
      "n": null,
      "doi": "10.3389/fnagi.2025.1632236",
      "value": "60%",
      "n_analyzed": null,
      "n_definition": "varies by study",
      "scope_region": "brain-wide / specific regions per study",
      "study_system": "rat",
      "scope_population": "rat",
      "value_source_sentence": "Histological evidence indicates that the number of LC neurons decreases by 60% in AD patients ( Mann et al."
    }
  ],
  "x_axis": "Brain state (Wake / NREM / REM)",
  "y_axis": "Relative neuromodulator activity",
  "figure_id": "fig_sec8_state_transitions_modulator",
  "comparison_type": "cross-modulator state-dependent activity comparison",
  "homogeneity_check": {
    "caveats": [
      "Different modulators measured with different techniques across studies",
      "Wake/NREM/REM classifications may differ between labs",
      "Activity measures vary: firing rate, release, sensor signal"
    ],
    "comparable": true
  }
}

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  "paper:paper-4589708b8bef",
  "paper:paper-4bb1fd558795",
  "paper:paper-583fee8051cd",
  "paper:paper-943ff5b178ab",
  "paper:paper-9ba29c77ce3c",
  "paper:paper-d0678479a944",
  "paper:paper-fdba5225b90e"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}