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{ "kind": "infographic", "prompt": "Neuromodulatory changes during brain state transitions (wake-NREM-REM)", "provider": "other", "raw_fields": { "title": "Neuromodulatory changes during brain state transitions (wake-NREM-REM)", "papers": [ { "n": 16, "doi": "10.1126/science.adq5233", "value": "200 nM", "n_analyzed": 16, "n_definition": "varies by study", "scope_region": "brain-wide / specific regions per study", "study_system": "computational model", "scope_population": "computational model", "value_source_sentence": "( H ) Experimental schematic: in vivo widefield imaging during chemogenetic activation of Tg(gfap:rTRPV1-eGFP) fish with 200 nM capsaicin in the presence of a neural activity blocker (170 mg/L MS-" }, { "n": null, "doi": "10.1016/j.neuron.2025.02.004", "value": "50%", "n_analyzed": null, "n_definition": "varies by study", "scope_region": "brain-wide / specific regions per study", "study_system": "rat", "scope_population": "rat", "value_source_sentence": "N1 is the transitional phase between wakefulness and sleep, occurring when more than 50% of alpha waves in electroencephalogram (EEG) recordings are replaced with low-amplitude, mixed-frequency activi" }, { "n": 29, "doi": "10.1126/sciadv.adi0643", "value": "100 μM", "n_analyzed": 29, "n_definition": "varies by study", "scope_region": "brain-wide / specific regions per study", "study_system": "rat", "scope_population": "rat", "value_source_sentence": "0 sensor under baseline and with 100 μM ACh." }, { "n": null, "doi": "10.3390/ijms262110766", "value": "20%", "n_analyzed": null, "n_definition": "varies by study", "scope_region": "brain-wide / specific regions per study", "study_system": "rat", "scope_population": "rat", "value_source_sentence": "provided direct electrophysiological evidence that cortical pyramidal neurons and hippocampal granule cells exhibit statistically significant daily fluctuations in membrane capacitance, with amplitude" }, { "n": null, "doi": "10.3389/fnins.2024.1426189", "value": "4 Hz", "n_analyzed": null, "n_definition": "varies by study", "scope_region": "brain-wide / specific regions per study", "study_system": "mouse", "scope_population": "mouse", "value_source_sentence": "5–4 Hz oscillatory activity which occur within NREM sleep as the result of the simultaneous activation and subsequent inactivation of large neural populations." }, { "n": null, "doi": "10.3389/fncel.2025.1606265", "value": "4 Hz", "n_analyzed": null, "n_definition": "varies by study", "scope_region": "brain-wide / specific regions per study", "study_system": "rat", "scope_population": "rat", "value_source_sentence": "5–4 Hz ( Kim et al." }, { "n": null, "doi": "10.1371/journal.pcbi.1012262", "value": "50%", "n_analyzed": null, "n_definition": "varies by study", "scope_region": "brain-wide / specific regions per study", "study_system": "rat", "scope_population": "rat", "value_source_sentence": "Notably, the number of thalamo-cortical outgoing axons is approximately one-tenth of the number of cortico-thalamic incoming axons [ 4 , 5 ], and the cortex is the major source of synapses within the" }, { "n": null, "doi": "10.3389/fnagi.2025.1632236", "value": "60%", "n_analyzed": null, "n_definition": "varies by study", "scope_region": "brain-wide / specific regions per study", "study_system": "rat", "scope_population": "rat", "value_source_sentence": "Histological evidence indicates that the number of LC neurons decreases by 60% in AD patients ( Mann et al." } ], "x_axis": "Brain state (Wake / NREM / REM)", "y_axis": "Relative neuromodulator activity", "figure_id": "fig_sec8_state_transitions_modulator", "comparison_type": "cross-modulator state-dependent activity comparison", "homogeneity_check": { "caveats": [ "Different modulators measured with different techniques across studies", "Wake/NREM/REM classifications may differ between labs", "Activity measures vary: firing rate, release, sensor signal" ], "comparable": true } }, "section_id": "section_08_evidence", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation/blob/95db5c630fe54e183d9c452cf826ce502d4a872d/evidence/section_08_evidence.json", "target_ref": "wiki_page:computationalreviewneuromodulation-08", "review_repo": "ComputationalReviewNeuromodulation", "section_ref": "wiki_page:computationalreviewneuromodulation-08", "source_path": "evidence/section_08_evidence.json", "source_refs": [ "paper:paper-2f2d9a7ca2d6", "paper:paper-4589708b8bef", "paper:paper-4bb1fd558795", "paper:paper-583fee8051cd", "paper:paper-943ff5b178ab", "paper:paper-9ba29c77ce3c", "paper:paper-d0678479a944", "paper:paper-fdba5225b90e" ], "section_title": "Cross-System Interactions and Brain-Wide States", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation" }, "generation_status": "complete", "review_bundle_ref": "analysis_bundle:ab-a3dbbaf9b625", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation/blob/95db5c630fe54e183d9c452cf826ce502d4a872d/evidence/section_08_evidence.json", "commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation" }