SST Interneuron Functional Properties Across Cortical Areas

{
  "papers": [
    {
      "doi": "10.1038/nn.3051",
      "value": "Unique properties of SST neurons in barrel cortex including lower firing rates",
      "method": "in vivo whole-cell recording",
      "metric": "SST functional properties",
      "cite_key": "Gentet2012",
      "condition": "barrel cortex (S1)",
      "study_system": "mouse",
      "value_source_sentence": "Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex."
    },
    {
      "doi": "10.1038/nature11526",
      "value": "SST neurons mediate surround suppression in V1",
      "method": "optogenetics",
      "metric": "SST functional role",
      "cite_key": "Adesnik2012",
      "condition": "visual cortex (V1)",
      "study_system": "mouse",
      "value_source_sentence": "A neural circuit for spatial summation in visual cortex."
    },
    {
      "doi": "10.1038/nature12676",
      "value": "SST neurons suppressed by VIP during reinforcement in A1",
      "method": "optogenetics + electrophysiology",
      "metric": "SST functional role",
      "cite_key": "Pi2013",
      "condition": "auditory cortex (A1) and mPFC",
      "study_system": "mouse",
      "value_source_sentence": "Cortical interneurons that specialize in disinhibitory control."
    },
    {
      "doi": "10.1038/nature12176",
      "value": "SST neurons show choice-specific modulation in PFC",
      "method": "optogenetic tagging + electrophysiology",
      "metric": "SST behavioral correlates",
      "cite_key": "Kvitsiani2013",
      "condition": "prefrontal cortex (PFC)",
      "study_system": "mouse",
      "value_source_sentence": "Distinct behavioural and network correlates of two interneuron types in prefrontal cortex."
    },
    {
      "doi": "10.1038/nn.3544",
      "value": "SST suppressed by VIP for motor integration in S1",
      "method": "optogenetics",
      "metric": "SST functional role",
      "cite_key": "Lee2013",
      "condition": "somatosensory cortex (S1)",
      "study_system": "mouse",
      "value_source_sentence": "A disinhibitory circuit mediates motor integration in the somatosensory cortex."
    }
  ],
  "comparison_id": "sst-cross-area-function",
  "comparison_name": "SST Interneuron Functional Properties Across Cortical Areas",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "SST neurons appear to serve similar circuit motifs (dendritic inhibition, VIP-SST interaction) across areas but their behavioral correlates are area-specific.",
  "homogeneity_check": {
    "caveats": [
      "All mouse studies using SST-Cre lines",
      "Different methods and behavioral paradigms per area",
      "Cross-area comparison is qualitative, not quantitative"
    ],
    "comparable": true
  },
  "suggested_plot_type": "heatmap"
}

[
  "paper:paper-065a0eae69a5",
  "paper:paper-1354264d555a",
  "paper:paper-48f7973b62f1",
  "paper:paper-f02f24cb44ff",
  "paper:paper-f8c7cbda4ea7"
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}