Version history

{
  "kind": "infographic",
  "prompt": "SST neurons appear to serve similar circuit motifs (dendritic inhibition, VIP-SST interaction) across areas but their behavioral correlates are area-specific.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/nn.3051",
        "value": "Unique properties of SST neurons in barrel cortex including lower firing rates",
        "method": "in vivo whole-cell recording",
        "metric": "SST functional properties",
        "cite_key": "Gentet2012",
        "condition": "barrel cortex (S1)",
        "study_system": "mouse",
        "value_source_sentence": "Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex."
      },
      {
        "doi": "10.1038/nature11526",
        "value": "SST neurons mediate surround suppression in V1",
        "method": "optogenetics",
        "metric": "SST functional role",
        "cite_key": "Adesnik2012",
        "condition": "visual cortex (V1)",
        "study_system": "mouse",
        "value_source_sentence": "A neural circuit for spatial summation in visual cortex."
      },
      {
        "doi": "10.1038/nature12676",
        "value": "SST neurons suppressed by VIP during reinforcement in A1",
        "method": "optogenetics + electrophysiology",
        "metric": "SST functional role",
        "cite_key": "Pi2013",
        "condition": "auditory cortex (A1) and mPFC",
        "study_system": "mouse",
        "value_source_sentence": "Cortical interneurons that specialize in disinhibitory control."
      },
      {
        "doi": "10.1038/nature12176",
        "value": "SST neurons show choice-specific modulation in PFC",
        "method": "optogenetic tagging + electrophysiology",
        "metric": "SST behavioral correlates",
        "cite_key": "Kvitsiani2013",
        "condition": "prefrontal cortex (PFC)",
        "study_system": "mouse",
        "value_source_sentence": "Distinct behavioural and network correlates of two interneuron types in prefrontal cortex."
      },
      {
        "doi": "10.1038/nn.3544",
        "value": "SST suppressed by VIP for motor integration in S1",
        "method": "optogenetics",
        "metric": "SST functional role",
        "cite_key": "Lee2013",
        "condition": "somatosensory cortex (S1)",
        "study_system": "mouse",
        "value_source_sentence": "A disinhibitory circuit mediates motor integration in the somatosensory cortex."
      }
    ],
    "comparison_id": "sst-cross-area-function",
    "comparison_name": "SST Interneuron Functional Properties Across Cortical Areas",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "SST neurons appear to serve similar circuit motifs (dendritic inhibition, VIP-SST interaction) across areas but their behavioral correlates are area-specific.",
    "homogeneity_check": {
      "caveats": [
        "All mouse studies using SST-Cre lines",
        "Different methods and behavioral paradigms per area",
        "Cross-area comparison is qualitative, not quantitative"
      ],
      "comparable": true
    },
    "suggested_plot_type": "heatmap"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-08",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-08",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-065a0eae69a5",
    "paper:paper-1354264d555a",
    "paper:paper-48f7973b62f1",
    "paper:paper-f02f24cb44ff",
    "paper:paper-f8c7cbda4ea7"
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}