Local Circuit Motifs and the Disinhibition Framework

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^{1Citationpaper:paper-1659c2dc5d60The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{7Citationpaper:paper-73696115e165The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference} The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}0 The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}1 The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}2 The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}3 The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}4 The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}5 The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}6 The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}7 The motif we now recite as disinhibitory was constructed from a tight cluster of 2013–2014 papers that combined cell-type-specific optogenetics, paired patch recordings, and in vivo two-photon imaging in mouse neocortex. ^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}8 mapped the inhibitory connections among PV, SST, and VIP cells in V1 layers 2/3 and 5 and reported a complementary connectivity scheme: PV cells preferentially inhibited PV cells a...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}9 The motif we now recite as disinhibitory was constructed from a tight cluster of 2013–2014 papers that combined cell-type-specific optogenetics, paired patch recordings, and in vivo two-photon imaging in mouse neocortex. ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}0 mapped the inhibitory connections among PV, SST, and VIP cells in V1 layers 2/3 and 5 and reported a complementary connectivity scheme: PV cells preferentially inhibited PV cells a...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}1 The motif we now recite as disinhibitory was constructed from a tight cluster of 2013–2014 papers that combined cell-type-specific optogenetics, paired patch recordings, and in vivo two-photon imaging in mouse neocortex. ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}2 mapped the inhibitory connections among PV, SST, and VIP cells in V1 layers 2/3 and 5 and reported a complementary connectivity scheme: PV cells preferentially inhibited PV cells a...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}3 The motif we now recite as disinhibitory was constructed from a tight cluster of 2013–2014 papers that combined cell-type-specific optogenetics, paired patch recordings, and in vivo two-photon imaging in mouse neocortex. ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}4 mapped the inhibitory connections among PV, SST, and VIP cells in V1 layers 2/3 and 5 and reported a complementary connectivity scheme: PV cells preferentially inhibited PV cells a...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}5 The motif we now recite as disinhibitory was constructed from a tight cluster of 2013–2014 papers that combined cell-type-specific optogenetics, paired patch recordings, and in vivo two-photon imaging in mouse neocortex. ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}6 mapped the inhibitory connections among PV, SST, and VIP cells in V1 layers 2/3 and 5 and reported a complementary connectivity scheme: PV cells preferentially inhibited PV cells a...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}7 A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}sec-cross-areas). Second, the disinhibitory recruitment story is a composite: top-down cortical glutamatergic drive ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}8 and ascending cholinergic and no...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}9 A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}sec-cross-areas). Second, the disinhibitory recruitment story is a composite: top-down cortical glutamatergic drive ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}0 and ascending cholinergic and no...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}1 A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}sec-cross-areas). Second, the disinhibitory recruitment story is a composite: top-down cortical glutamatergic drive ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}2 and ascending cholinergic and no...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}3 A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}sec-cross-areas). Second, the disinhibitory recruitment story is a composite: top-down cortical glutamatergic drive ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}4 and ascending cholinergic and no...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}5 A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}sec-cross-areas). Second, the disinhibitory recruitment story is a composite: top-down cortical glutamatergic drive ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}6 and ascending cholinergic and no...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}7 A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}sec-cross-areas). Second, the disinhibitory recruitment story is a composite: top-down cortical glutamatergic drive ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}8 and ascending cholinergic and no...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}9 A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}sec-cross-areas). Second, the disinhibitory recruitment story is a composite: top-down cortical glutamatergic drive ^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}0 and ascending cholinergic and no...
^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}1 A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}sec-cross-areas). Second, the disinhibitory recruitment story is a composite: top-down cortical glutamatergic drive ^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}2 and ascending cholinergic and no...
^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}3 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}4. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}5 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}6. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}7 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}8. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{5Citationpaper:paper-d405e5906927The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}9 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}0. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}1 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}2. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}3 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}4. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}5 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}6. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}7 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}8. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{2Citationpaper:paper-065a0eae69a5The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}9 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}0. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}1 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}2. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}3 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}4. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}5 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}6. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}7 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}8. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{3Citationpaper:paper-f02f24cb44ffThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}9 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}0. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}1 The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}2. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}3 These two routes are typically presented as alternatives, but the experimental evidence is most cleanly read as showing that they cooperate. ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}4 recorded VIP and SST cells during a frontal-cortex task and characterised cell-type-specific activity profiles during cognitively demanding behaviour. ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}5 reported that PFC VIP cells in delayed-response tasks integrated cue and reward-related inputs that...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}6 These two routes are typically presented as alternatives, but the experimental evidence is most cleanly read as showing that they cooperate. ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}7 recorded VIP and SST cells during a frontal-cortex task and characterised cell-type-specific activity profiles during cognitively demanding behaviour. ^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}8 reported that PFC VIP cells in delayed-response tasks integrated cue and reward-related inputs that...
^{4Citationpaper:paper-5cfe39bf225dThe synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}9 These two routes are typically presented as alternatives, but the experimental evidence is most cleanly read as showing that they cooperate. ^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}0 recorded VIP and SST cells during a frontal-cortex task and characterised cell-type-specific activity profiles during cognitively demanding behaviour. ^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}1 reported that PFC VIP cells in delayed-response tasks integrated cue and reward-related inputs that...
^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}2 These two routes are typically presented as alternatives, but the experimental evidence is most cleanly read as showing that they cooperate. ^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}3 recorded VIP and SST cells during a frontal-cortex task and characterised cell-type-specific activity profiles during cognitively demanding behaviour. ^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}4 reported that PFC VIP cells in delayed-response tasks integrated cue and reward-related inputs that...
^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}5 These two routes are typically presented as alternatives, but the experimental evidence is most cleanly read as showing that they cooperate. ^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}6 recorded VIP and SST cells during a frontal-cortex task and characterised cell-type-specific activity profiles during cognitively demanding behaviour. ^{6Citationpaper:paper-05bd6c97da43The synaptic inventory assembled in {ref}sec-synaptic-properties — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...content/07_disinhibition_framework.md:line 5Open reference}7 reported that PFC VIP cells in delayed-response tasks integrated cue and reward-related inputs that...
... 281 additional anchors in refs_json

References

[Pfeffer2013] paper:paper-1659c2dc5d60 “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Pi2013] paper:paper-065a0eae69a5 “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Lee2013] paper:paper-f02f24cb44ff “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Fu2014] paper:paper-5cfe39bf225d “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Karnani2016a] paper:paper-d405e5906927 “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Zhang2014] paper:paper-05bd6c97da43 “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Kuchibhotla2017] paper:paper-73696115e165 “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Cichon2017] paper:paper-d00f7f72db9b “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Williams2019] paper:paper-55f18434021b “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Veit2023] paper:paper-d895aafe5d83 “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Pakan2016] paper:paper-acf576c0a2ed “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Dipoppa2018] paper:paper-f457e091013f “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Garrett2020] paper:paper-14e8bef771dc “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Stachniak2021] paper:paper-b5b2bae45f13 “The synaptic inventory assembled in {ref}`sec-synaptic-properties` — strong long-range and neuromodulatory drive onto VIP cells, asymmetric output that favours somatostatin (SST) interneurons but does not spare parvalbumin (PV) cells or pyramidal neurons — supplies the parts list for a circuit-level reading. The question this section addresses is what circuit motif those parts implement, and whether the standard ans...”
[Hangya2015] paper:paper-18cf823377e3 “A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}`sec-cross-areas`). Second, the disinhibitory recruitment story is a *composite*: top-down cortical glutamatergic drive [Lee2013,Zhang2014] and ascending cholinergic and no...”
[Karnani2016b] paper:paper-0a3cf7627c63 “A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}`sec-cross-areas`). Second, the disinhibitory recruitment story is a *composite*: top-down cortical glutamatergic drive [Lee2013,Zhang2014] and ascending cholinergic and no...”
[Yu2019] paper:e5dc2921-2ba0-4d4f-a34c-67e2b13a356d “A few features of this construction deserve emphasis. First, the disinhibitory schematic was tested predominantly in superficial layers of mouse V1 and primary auditory cortex; PFC, M1, and S1 evidence followed and is more heterogeneous (see {ref}`sec-cross-areas`). Second, the disinhibitory recruitment story is a *composite*: top-down cortical glutamatergic drive [Lee2013,Zhang2014] and ascending cholinergic and no...”
[Pinto2015] paper:paper-6fb6c7efe883 “The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli [Fu2014,Pinto2015,Pakan2016,Dipoppa2018,Garrett2020]. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...”
[Anastasiades2021a] paper:paper-7227d2a3ed3e “The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli [Fu2014,Pinto2015,Pakan2016,Dipoppa2018,Garrett2020]. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...”
[Mcfarlan2024a] paper:paper-c141a5bf864f “The recruitment side of the disinhibitory motif is settled in outline and unsettled in detail. In outline: VIP cells in adult cortex are reliably activated by behavioural events that combine arousal, locomotion, and salient external stimuli [Fu2014,Pinto2015,Pakan2016,Dipoppa2018,Garrett2020]. In detail: at least three partially overlapping recruitment routes have been documented and their relative weights are area-...”
[Kamigaki2017] paper:paper-6552e7a00e2e “These two routes are typically presented as alternatives, but the experimental evidence is most cleanly read as showing that they cooperate. [Pinto2015] recorded VIP and SST cells during a frontal-cortex task and characterised cell-type-specific activity profiles during cognitively demanding behaviour. [Kamigaki2017] reported that PFC VIP cells in delayed-response tasks integrated cue and reward-related inputs that...”
[Garciadelmolino2017] paper:paper-e67fae66877b “These two routes are typically presented as alternatives, but the experimental evidence is most cleanly read as showing that they cooperate. [Pinto2015] recorded VIP and SST cells during a frontal-cortex task and characterised cell-type-specific activity profiles during cognitively demanding behaviour. [Kamigaki2017] reported that PFC VIP cells in delayed-response tasks integrated cue and reward-related inputs that...”
[Hertag2019] paper:paper-485852ecd519 “These two routes are typically presented as alternatives, but the experimental evidence is most cleanly read as showing that they cooperate. [Pinto2015] recorded VIP and SST cells during a frontal-cortex task and characterised cell-type-specific activity profiles during cognitively demanding behaviour. [Kamigaki2017] reported that PFC VIP cells in delayed-response tasks integrated cue and reward-related inputs that...”

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