Molecular Identity and Transcriptomic Taxonomy

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^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference} The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference} consolidated immunohistochemical, electrophy...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference} The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference} consolidated immunohistochemical, electrophy...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference} The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference} consolidated immunohistochemical, electrophy...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference} The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1 consolidated immunohistochemical, electrophy...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 consolidated immunohistochemical, electrophy...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 consolidated immunohistochemical, electrophy...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 The CGE-derived 5-HT3AR class is internally heterogeneous. Triple immunostaining of mouse visual cortex resolved at least thirteen combinatorial groups of cortical GABAergic neurons defined by overlapping expression of PV, CR, SST, CCK, NPY, VIP, and ChAT ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9, and double-label quantification across cortex confirmed that PV, SST, and VIP define three reliably non-overlapping subpopulations while CR and NPY...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0 The CGE-derived 5-HT3AR class is internally heterogeneous. Triple immunostaining of mouse visual cortex resolved at least thirteen combinatorial groups of cortical GABAergic neurons defined by overlapping expression of PV, CR, SST, CCK, NPY, VIP, and ChAT ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1, and double-label quantification across cortex confirmed that PV, SST, and VIP define three reliably non-overlapping subpopulations while CR and NPY...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 The CGE-derived 5-HT3AR class is internally heterogeneous. Triple immunostaining of mouse visual cortex resolved at least thirteen combinatorial groups of cortical GABAergic neurons defined by overlapping expression of PV, CR, SST, CCK, NPY, VIP, and ChAT ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3, and double-label quantification across cortex confirmed that PV, SST, and VIP define three reliably non-overlapping subpopulations while CR and NPY...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0 Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field’s reference frame. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1 profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 The robustness of the subclass framework is not just an aesthetic claim about clustering. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3 formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (Vip, Sst, Pvalb) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 The robustness of the subclass framework is not just an aesthetic claim about clustering. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (Vip, Sst, Pvalb) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6 The robustness of the subclass framework is not just an aesthetic claim about clustering. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (Vip, Sst, Pvalb) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 The robustness of the subclass framework is not just an aesthetic claim about clustering. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9 formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (Vip, Sst, Pvalb) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0 The robustness of the subclass framework is not just an aesthetic claim about clustering. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1 formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (Vip, Sst, Pvalb) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 The robustness of the subclass framework is not just an aesthetic claim about clustering. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3 formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (Vip, Sst, Pvalb) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 The number of “VIP types” reported by an atlas is a function of clustering depth, not a measurement of biological discreteness. The clearest demonstration of this is the contrast between two studies from the same Allen Institute laboratory: ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 resolved approximately five Vip t-types in mouse V1, while ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6 identified roughly fourteen Vip t-types across VISp and ALM. The expansion was not a contra...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 The number of “VIP types” reported by an atlas is a function of clustering depth, not a measurement of biological discreteness. The clearest demonstration of this is the contrast between two studies from the same Allen Institute laboratory: ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 resolved approximately five Vip t-types in mouse V1, while ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9 identified roughly fourteen Vip t-types across VISp and ALM. The expansion was not a contra...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0 The number of “VIP types” reported by an atlas is a function of clustering depth, not a measurement of biological discreteness. The clearest demonstration of this is the contrast between two studies from the same Allen Institute laboratory: ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1 resolved approximately five Vip t-types in mouse V1, while ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 identified roughly fourteen Vip t-types across VISp and ALM. The expansion was not a contra...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3 The number of “VIP types” reported by an atlas is a function of clustering depth, not a measurement of biological discreteness. The clearest demonstration of this is the contrast between two studies from the same Allen Institute laboratory: ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 resolved approximately five Vip t-types in mouse V1, while ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 identified roughly fourteen Vip t-types across VISp and ALM. The expansion was not a contra...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6 The number of “VIP types” reported by an atlas is a function of clustering depth, not a measurement of biological discreteness. The clearest demonstration of this is the contrast between two studies from the same Allen Institute laboratory: ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 resolved approximately five Vip t-types in mouse V1, while ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 identified roughly fourteen Vip t-types across VISp and ALM. The expansion was not a contra...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0 reported approximately five Vip transcriptomic types in mouse V1, whereas ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1 recovered roughly fourteen Vip t-types in mouse VISp+ALM, an ostensibly large expansion within two years from the same laboratory. The disagreement reflects taxonomic depth rather than biology: clustering resolution, cell number, and area sampling were all increased. The Vip subclass and its supertype-level subdiv...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3 reported approximately five Vip transcriptomic types in mouse V1, whereas ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 recovered roughly fourteen Vip t-types in mouse VISp+ALM, an ostensibly large expansion within two years from the same laboratory. The disagreement reflects taxonomic depth rather than biology: clustering resolution, cell number, and area sampling were all increased. The Vip subclass and its supertype-level subdiv...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6 reported approximately five Vip transcriptomic types in mouse V1, whereas ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 recovered roughly fourteen Vip t-types in mouse VISp+ALM, an ostensibly large expansion within two years from the same laboratory. The disagreement reflects taxonomic depth rather than biology: clustering resolution, cell number, and area sampling were all increased. The Vip subclass and its supertype-level subdiv...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9 reported approximately five Vip transcriptomic types in mouse V1, whereas ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0 recovered roughly fourteen Vip t-types in mouse VISp+ALM, an ostensibly large expansion within two years from the same laboratory. The disagreement reflects taxonomic depth rather than biology: clustering resolution, cell number, and area sampling were all increased. The Vip subclass and its supertype-level subdiv...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 reported approximately five Vip transcriptomic types in mouse V1, whereas ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3 recovered roughly fourteen Vip t-types in mouse VISp+ALM, an ostensibly large expansion within two years from the same laboratory. The disagreement reflects taxonomic depth rather than biology: clustering resolution, cell number, and area sampling were all increased. The Vip subclass and its supertype-level subdiv...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 reported approximately five Vip transcriptomic types in mouse V1, whereas ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6 recovered roughly fourteen Vip t-types in mouse VISp+ALM, an ostensibly large expansion within two years from the same laboratory. The disagreement reflects taxonomic depth rather than biology: clustering resolution, cell number, and area sampling were all increased. The Vip subclass and its supertype-level subdiv...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 The same instability appears when transcriptomic taxonomies are compared against the marker-protein subdivisions that pre-existed scRNA-seq. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 reviewed the immunohistochemical and slice-electrophysiology literature and proposed three principal VIP subdivisions defined by secondary marker expression: VIP/CCK multipolar basket cells, VIP/CR irregular-spiking bipolar cells, and a small VIP/ChAT bipolar sub...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9 The same instability appears when transcriptomic taxonomies are compared against the marker-protein subdivisions that pre-existed scRNA-seq. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}0 reviewed the immunohistochemical and slice-electrophysiology literature and proposed three principal VIP subdivisions defined by secondary marker expression: VIP/CCK multipolar basket cells, VIP/CR irregular-spiking bipolar cells, and a small VIP/ChAT bipolar sub...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}1 The same instability appears when transcriptomic taxonomies are compared against the marker-protein subdivisions that pre-existed scRNA-seq. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}2 reviewed the immunohistochemical and slice-electrophysiology literature and proposed three principal VIP subdivisions defined by secondary marker expression: VIP/CCK multipolar basket cells, VIP/CR irregular-spiking bipolar cells, and a small VIP/ChAT bipolar sub...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}3 The same instability appears when transcriptomic taxonomies are compared against the marker-protein subdivisions that pre-existed scRNA-seq. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}4 reviewed the immunohistochemical and slice-electrophysiology literature and proposed three principal VIP subdivisions defined by secondary marker expression: VIP/CCK multipolar basket cells, VIP/CR irregular-spiking bipolar cells, and a small VIP/ChAT bipolar sub...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}5 The same instability appears when transcriptomic taxonomies are compared against the marker-protein subdivisions that pre-existed scRNA-seq. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}6 reviewed the immunohistochemical and slice-electrophysiology literature and proposed three principal VIP subdivisions defined by secondary marker expression: VIP/CCK multipolar basket cells, VIP/CR irregular-spiking bipolar cells, and a small VIP/ChAT bipolar sub...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}7 The same instability appears when transcriptomic taxonomies are compared against the marker-protein subdivisions that pre-existed scRNA-seq. ^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}8 reviewed the immunohistochemical and slice-electrophysiology literature and proposed three principal VIP subdivisions defined by secondary marker expression: VIP/CCK multipolar basket cells, VIP/CR irregular-spiking bipolar cells, and a small VIP/ChAT bipolar sub...
^{2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}9 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}00 reviewed VIP heterogeneity as approximately three marker-defined subdivisions (VIP/CCK, VIP/CR, VIP/ChAT) supported by combinatorial immunohistochemistry and slice physiology. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}01 resolved progenitor-stage transcriptomic signatures that already segregate the cardinal interneuron lineages, including a Vip precursor population, broadly consistent with the within-class type counts of contempora...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}02 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}03 reviewed VIP heterogeneity as approximately three marker-defined subdivisions (VIP/CCK, VIP/CR, VIP/ChAT) supported by combinatorial immunohistochemistry and slice physiology. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}04 resolved progenitor-stage transcriptomic signatures that already segregate the cardinal interneuron lineages, including a Vip precursor population, broadly consistent with the within-class type counts of contempora...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}05 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}06 reviewed VIP heterogeneity as approximately three marker-defined subdivisions (VIP/CCK, VIP/CR, VIP/ChAT) supported by combinatorial immunohistochemistry and slice physiology. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}07 resolved progenitor-stage transcriptomic signatures that already segregate the cardinal interneuron lineages, including a Vip precursor population, broadly consistent with the within-class type counts of contempora...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}08 ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}09 reviewed VIP heterogeneity as approximately three marker-defined subdivisions (VIP/CCK, VIP/CR, VIP/ChAT) supported by combinatorial immunohistochemistry and slice physiology. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}10 resolved progenitor-stage transcriptomic signatures that already segregate the cardinal interneuron lineages, including a Vip precursor population, broadly consistent with the within-class type counts of contempora...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}11 The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}12 and ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}13 distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}14 further showed that cholinergic agonists se...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}15 The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}16 and ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}17 distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}18 further showed that cholinergic agonists se...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}19 The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}20 and ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}21 distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}22 further showed that cholinergic agonists se...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}23 The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}24 and ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}25 distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}26 further showed that cholinergic agonists se...
^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}27 The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}28 and ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}29 distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. ^{1Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference, 2Citationpaper:paper-53c8505de50fThe modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...content/02_classification.md:line 9Open reference}30 further showed that cholinergic agonists se...
... 138 additional anchors in refs_json

References

[Rudy2011] paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9 “The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...”
[Tremblay2016] paper:paper-53c8505de50f “The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...”
[Lee2010] paper:paper-9cfdde391cfd “The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...”
[Tamamaki2003] paper:paper-27b839768dcb “The modern partition of cortical GABAergic interneurons rests on a tripartite scheme in which essentially every neocortical inhibitory neuron expresses one of three principal markers — parvalbumin (PV), somatostatin (SST), or the ionotropic serotonin receptor 5-HT3AR — accounting between them for nearly the entire interneuron population [Rudy2011,Tremblay2016]. [Rudy2011] consolidated immunohistochemical, electrophy...”
[Gonchar2008] paper:paper-35d664630898 “The CGE-derived 5-HT3AR class is internally heterogeneous. Triple immunostaining of mouse visual cortex resolved at least thirteen combinatorial groups of cortical GABAergic neurons defined by overlapping expression of PV, CR, SST, CCK, NPY, VIP, and ChAT [Gonchar2008], and double-label quantification across cortex confirmed that PV, SST, and VIP define three reliably non-overlapping subpopulations while CR and NPY...”
[Xu2010a] paper:paper-f74768c3fc02 “The CGE-derived 5-HT3AR class is internally heterogeneous. Triple immunostaining of mouse visual cortex resolved at least thirteen combinatorial groups of cortical GABAergic neurons defined by overlapping expression of PV, CR, SST, CCK, NPY, VIP, and ChAT [Gonchar2008], and double-label quantification across cortex confirmed that PV, SST, and VIP define three reliably non-overlapping subpopulations while CR and NPY...”
[Pronneke2015] paper:paper-8e91417bef90 “The CGE-derived 5-HT3AR class is internally heterogeneous. Triple immunostaining of mouse visual cortex resolved at least thirteen combinatorial groups of cortical GABAergic neurons defined by overlapping expression of PV, CR, SST, CCK, NPY, VIP, and ChAT [Gonchar2008], and double-label quantification across cortex confirmed that PV, SST, and VIP define three reliably non-overlapping subpopulations while CR and NPY...”
[Tasic2016] paper:paper-ed2a7f08ef35 “Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field's reference frame. [Tasic2016] profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...”
[Tasic2018] paper:paper-pm-30382198 “Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field's reference frame. [Tasic2016] profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...”
[Yao2021b] paper:paper-0c694a60c289 “Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field's reference frame. [Tasic2016] profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...”
[Yao2021a] paper:paper-4dfe44516146 “Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field's reference frame. [Tasic2016] profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...”
[Yao2023] paper:1f98e15e-de06-42f7-9da8-1faa69bba835 “Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field's reference frame. [Tasic2016] profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...”
[Zeisel2015] paper:paper-6e5df2cb10ba “Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field's reference frame. [Tasic2016] profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...”
[Zeisel2018] paper:paper-063a15662345 “Single-cell transcriptomics consolidated the VIP/SST/PV/Lamp5 subclass partition into a hierarchical scheme that is now the field's reference frame. [Tasic2016] profiled 1,679 high-quality single cells from adult mouse primary visual cortex with SMART-seq and recovered forty-nine transcriptomic types — twenty-three GABAergic, nineteen glutamatergic, and seven non-neuronal — with the GABAergic types organised around...”
[Crow2018] paper:paper-788ccd1dc2b2 “The robustness of the subclass framework is not just an aesthetic claim about clustering. [Crow2018] formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (*Vip*, *Sst*, *Pvalb*) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...”
[Gouwens2020a] paper:paper-pm-33186530 “The robustness of the subclass framework is not just an aesthetic claim about clustering. [Crow2018] formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (*Vip*, *Sst*, *Pvalb*) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...”
[Nandi2022] paper:paper-pm-35947954 “The robustness of the subclass framework is not just an aesthetic claim about clustering. [Crow2018] formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (*Vip*, *Sst*, *Pvalb*) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...”
[Smith2019] paper:paper-pm-31710287 “The robustness of the subclass framework is not just an aesthetic claim about clustering. [Crow2018] formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (*Vip*, *Sst*, *Pvalb*) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...”
[Cadwell2016] paper:paper-1ce98e1d2969 “The robustness of the subclass framework is not just an aesthetic claim about clustering. [Crow2018] formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (*Vip*, *Sst*, *Pvalb*) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...”
[Fuzik2016] paper:paper-fd924ebdd0c4 “The robustness of the subclass framework is not just an aesthetic claim about clustering. [Crow2018] formalised the question with the MetaNeighbor framework and showed that the major cortical interneuron classes (*Vip*, *Sst*, *Pvalb*) replicate at high quantitative reliability across independent scRNA-seq datasets, whereas fine-grained subdivisions replicate progressively less well as taxonomic resolution increases...”
[Mayer2018] paper:paper-c3e9fd7af6d3 “The same instability appears when transcriptomic taxonomies are compared against the marker-protein subdivisions that pre-existed scRNA-seq. [Tremblay2016] reviewed the immunohistochemical and slice-electrophysiology literature and proposed three principal VIP subdivisions defined by secondary marker expression: VIP/CCK multipolar basket cells, VIP/CR irregular-spiking bipolar cells, and a small VIP/ChAT bipolar sub...”
[Paul2017] paper:paper-35a6c66c3e2e “The same instability appears when transcriptomic taxonomies are compared against the marker-protein subdivisions that pre-existed scRNA-seq. [Tremblay2016] reviewed the immunohistochemical and slice-electrophysiology literature and proposed three principal VIP subdivisions defined by secondary marker expression: VIP/CCK multipolar basket cells, VIP/CR irregular-spiking bipolar cells, and a small VIP/ChAT bipolar sub...”
[Kawaguchi1996] paper:paper-1934939df27a “The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. [Kawaguchi1996] and [Kawaguchi1997a] distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. [Kawaguchi1997b] further showed that cholinergic agonists se...”
[Kawaguchi1997a] paper:paper-0506337fc9e9 “The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. [Kawaguchi1996] and [Kawaguchi1997a] distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. [Kawaguchi1997b] further showed that cholinergic agonists se...”
[Kawaguchi1997b] paper:paper-3af861278dcc “The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. [Kawaguchi1996] and [Kawaguchi1997a] distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. [Kawaguchi1997b] further showed that cholinergic agonists se...”
[Toledorodriguez2005] paper:paper-add043f63e7d “The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. [Kawaguchi1996] and [Kawaguchi1997a] distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. [Kawaguchi1997b] further showed that cholinergic agonists se...”
[Wang2004b] paper:paper-0cee20f3440c “The combinatorial slice-electrophysiology and IHC studies that preceded scRNA-seq already foreshadowed this resolution-dependence. [Kawaguchi1996] and [Kawaguchi1997a] distinguished PV+ fast-spiking, late-spiking neurogliaform, and a heterogeneous regular- and burst-spiking group containing SST/Martinotti and VIP/double-bouquet cells in rat frontal cortex. [Kawaguchi1997b] further showed that cholinergic agonists se...”

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