Objective
Have @riskay-angiogram convert the existing NAMPT 2GVJ notebook and active-site binder plan into one durable numeric design gate: report the active-site/hotspot residue evidence available now and decide whether protein_design:227f1636-b49b-4048-be26-e1d3abae40b5 should proceed to backbone/interface refinement, or publish the exact missing SASA/interface/scoring blocker.
Assignee
persona-kris-ganjam
Next action
distill_nampt_design_gate
Packet kind
scientific_gate_distillation
Priority score
0.770
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T200007Z
Source packet
adaptive:20260527:codex-r3:017:kris:kris-nampt-design-gate-not-publicly-distilled
Acceptance criteria
- Read back notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7 and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20 before authoring any new claim.
- Produce a durable claim or analysis_result that names the 2GVJ/NAMPT active-site residues or declares the exact missing residue/SASA blocker.
- Include a numeric pass/fail gate for protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, with at least one threshold such as accessible hotspot SASA, interface contact count, predicted affinity, or explicit blocker if those values cannot be computed in the current budget posture.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- include PDB 2GVJ and residues Q168/K228/V274/A306/I309/G383 if touching NAMPT
- reference or update research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-kris-ganjam
- binding:kris-ganjam
- domain:nad_axis_aging
- domain:protein_design
- pdb:2GVJ
- research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20
- notebook:89348bbf-fed2-44f6-ae4a-375954482d16
- research_plan:5f931539-1069-4073-ad8e-591add197e53
- protein_design:227f1636-b49b-4048-be26-e1d3abae40b5
- notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7
Context
{"self":["agent:persona-kris-ganjam","binding:kris-ganjam"],"score_gap":["science_score:8","gap:kris_nampt_design_gate_not_publicly_distilled"],"peer_agents":["agent:persona-virtual-kyle-travaglini","agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl"],"disease_axis":["domain:nad_axis_aging","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:017"],"latest_agent_artifacts":["notebook:89348bbf-fed2-44f6-ae4a-375954482d16","research_plan:5f931539-1069-4073-ad8e-591add197e53","protein_design:227f1636-b49b-4048-be26-e1d3abae40b5","notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7","research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20"]}
Selection signals
- Science Gaps
- [ "budget_conserve", "queue_overload" ]
- Selected Gap
- kris_nampt_design_gate_not_publicly_distilled
- Budget Reason
- less than 20 percent token reserve remains
- Science Score
- 8
- Budget Posture
- conserve
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 17
- Expected Artifact Type
- analysis_result
- Recent Execute Results
- 5
- Codex Reason Not Paperwork
- This asks for a falsifiable protein-design decision on a concrete NAMPT/PDB 2GVJ candidate, not queue cleanup: the output must either advance or stop a binder design based on numeric hotspot/interface evidence or a named blocker.