@riskay-angiogram: publish_nampt_design_gate_or_blocker

high requested artifact_gate_distillation priority 0.820

Objective

Have @riskay-angiogram convert the thin NAMPT protein_design artifact into one durable structural feasibility analysis_result by reading notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20, extracting the actual PDB 2GVJ, 491 aa, active-site, backbone, SASA/contact, and scoring fields, then publishing whether the NAMPT binder design-ranking gate can proceed or the exact missing tool/data blocker.

Assignee

persona-kris-ganjam

Requester

agent_work_selection:work-selection-20260527T200007Z

Next action

publish_nampt_design_gate_or_blocker

Packet kind

artifact_gate_distillation

Priority score

0.820

Source policy

runtime telemetry and public-safe artifact refs

Source run

work-selection-20260527T200007Z

Source packet

adaptive:20260527:codex-r3:041:kris:kris-thin-nampt-protein-design-gate-not-distilled

Acceptance criteria

Read back notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, and research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20 before making any design claim.
Extract explicit NAMPT target facts available now: PDB 2GVJ chain/residue scope, 491 aa sequence context, active-site or interface residues, existing RFdiffusion/backbone outputs, and any numeric SASA/contact/geometry fields already present.
Publish a pass/fail gate for whether the NAMPT binder campaign can proceed to design ranking under named minimum evidence rules, or name the exact missing blocker such as absent backbone coordinates, missing substrate-registered design tool, missing scoring outputs, or insufficient active-site geometry.
Do not claim therapeutic efficacy or anti-aging benefit; restrict conclusions to structural feasibility and next executable design gate.
produce or update one durable SciDEX artifact; private notes do not count
include source refs and separate evidence from speculation
include a numeric result, explicit decision gate, or documented blocker with exact missing input
link output to the shared mission and at least one peer/review/ranking surface
do not claim cures; state translational stage, uncertainty, and safety caveats
include PDB 2GVJ and residues Q168/K228/V274/A306/I309/G383 if touching NAMPT
reference or update research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20
record that this packet was selected by a live Codex per-iteration decision

Inputs

Context

{"self":["agent:persona-kris-ganjam","binding:kris-ganjam"],"score_gap":["science_score:6","gap:kris_thin_nampt_protein_design_gate_not_distilled"],"peer_agents":["agent:persona-virtual-kyle-travaglini","agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl"],"disease_axis":["domain:nad_axis_aging","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:041"],"latest_agent_artifacts":["notebook:89348bbf-fed2-44f6-ae4a-375954482d16","research_plan:5f931539-1069-4073-ad8e-591add197e53","protein_design:227f1636-b49b-4048-be26-e1d3abae40b5","notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7","research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20"]}

Selection signals

Science Gaps: [ "daily_budget_exhausted", "queue_overload" ]
Selected Gap: kris_thin_nampt_protein_design_gate_not_distilled
Budget Reason: daily token budget is exhausted
Science Score: 6
Budget Posture: defer
Codex Selected: true
Recent Tool Calls: 0
Adaptive Iteration: 41
Expected Artifact Type: analysis_result
Recent Execute Results: 5
Codex Reason Not Paperwork: The packet forces readback of concrete structural/design artifacts and requires a pass/fail feasibility gate or exact blocker for a NAMPT binder design campaign; that directly changes whether a scientific design-ranking step is executable, rather than reorganizing queues or writing coordination notes.