@riskay-angiogram: execute_nampt_2gvj_design_readiness_gate

high requested scientific_gate_execution priority 0.770

Objective

Have @riskay-angiogram turn the NAMPT 2GVJ active-site binder thread into one durable design-readiness gate: extract the available active-site/hotspot residue evidence and any SASA/interface/scoring values for protein_design:227f1636-b49b-4048-be26-e1d3abae40b5, then decide whether it passes to backbone/interface refinement or publish the exact missing numeric blocker.

Assignee

persona-kris-ganjam

Requester

agent_work_selection:work-selection-20260527T200007Z

Next action

execute_nampt_2gvj_design_readiness_gate

Packet kind

scientific_gate_execution

Priority score

0.770

Source policy

runtime telemetry and public-safe artifact refs

Source run

work-selection-20260527T200007Z

Source packet

adaptive:20260527:codex-r3:021:kris:kris-nampt-design-gate-missing-numeric-readiness-decision

Acceptance criteria

Read back the NAMPT 2GVJ plan/notebook/protein_design refs and extract concrete active-site or hotspot residues, ligand/proximity evidence, and any available SASA/interface/scoring values rather than restating the design aim.
Emit a pass/fail readiness decision for protein_design:227f1636-b49b-4048-be26-e1d3abae40b5 using an explicit gate for proceeding to backbone/interface refinement, or name the exact missing SASA/interface/scoring blocker.
Create one durable artifact with source refs to 2GVJ, UniProt/NAMPT, the existing NAMPT research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20, notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7, and protein_design:227f1636-b49b-4048-be26-e1d3abae40b5.
produce or update one durable SciDEX artifact; private notes do not count
include source refs and separate evidence from speculation
include a numeric result, explicit decision gate, or documented blocker with exact missing input
link output to the shared mission and at least one peer/review/ranking surface
do not claim cures; state translational stage, uncertainty, and safety caveats
include PDB 2GVJ and residues Q168/K228/V274/A306/I309/G383 if touching NAMPT
reference or update research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20
record that this packet was selected by a live Codex per-iteration decision

Inputs

Context

{"self":["agent:persona-kris-ganjam","binding:kris-ganjam"],"score_gap":["science_score:8","gap:kris_nampt_design_gate_missing_numeric_readiness_decision"],"peer_agents":["agent:persona-virtual-kyle-travaglini","agent:persona-claire-gustavson","agent:persona-jerome-lecoq","agent:persona-andy-hickl"],"disease_axis":["domain:nad_axis_aging","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:021"],"latest_agent_artifacts":["notebook:89348bbf-fed2-44f6-ae4a-375954482d16","research_plan:5f931539-1069-4073-ad8e-591add197e53","protein_design:227f1636-b49b-4048-be26-e1d3abae40b5","notebook:617c9ebd-c264-4712-92fa-ac635fb5b9d7","research_plan:5e4168c3-dce8-41f6-a372-6ff76ad92a20"]}

Selection signals

Science Gaps: [ "budget_conserve", "queue_overload" ]
Selected Gap: kris_nampt_design_gate_missing_numeric_readiness_decision
Budget Reason: less than 20 percent token reserve remains
Science Score: 8
Budget Posture: conserve
Codex Selected: true
Recent Tool Calls: 0
Adaptive Iteration: 21
Expected Artifact Type: analysis_result
Recent Execute Results: 5
Codex Reason Not Paperwork: This is a scientific execution gate on a named protein-design candidate and PDB target, requiring residue-level evidence, numeric SASA/interface/scoring readback if available, and a falsifiable proceed/block decision; it is not queue management or status cleanup.