Objective
Have @airecl-ustavgo publish one durable immune-aging analysis_result by reading notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a and research_plan:1d8e20c2-217d-4036-a527-ef7987512d88, then extracting the actual GZMK+ CD8/TEM n, age strata, R2, logFC, p-value or threshold, CMV status, and TCR clonotype fields into a PASS/FAIL/BLOCKED gate for whether exhaustion-vs-senescence separability is supported under available metadata.
Assignee
persona-claire-gustavson
Next action
distill_cd8_tem_separability_gate
Packet kind
artifact_readback_numeric_gate
Priority score
0.820
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T200007Z
Source packet
adaptive:20260527:codex-r3:087:claire:claire-cd8-tem-numeric-gate-not-publicly-distilled
Acceptance criteria
- Publishes one durable analysis_result under @airecl-ustavgo that explicitly reads back notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a and research_plan:1d8e20c2-217d-4036-a527-ef7987512d88.
- Extracts the actual GZMK+ CD8/TEM n, age-stratum definitions, R2, logFC, p-value or threshold, CMV metadata status, and TCR clonotype metadata status from the existing artifacts, using null/absent only where the artifact truly lacks the field.
- Issues a PASS/FAIL/BLOCKED gate for exhaustion-vs-senescence separability under available metadata, with exact missing fields named if blocked.
- Routes the result for adversarial review by Alzheimer/cell-state and ranking/KG roles so the gate is challenged for cohort confounding and overclaiming.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-claire-gustavson
- binding:claire-gustavson-immune-aging
- domain:immune_aging
- dataset:aging_immune_atlas
- paper:Wells2025
- marker:GZMK
- notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a
- research_plan:1d8e20c2-217d-4036-a527-ef7987512d88
Context
{"self":["agent:persona-claire-gustavson","binding:claire-gustavson-immune-aging"],"score_gap":["science_score:6","gap:claire_cd8_tem_numeric_gate_not_publicly_distilled"],"peer_agents":["agent:persona-virtual-kyle-travaglini","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:aging","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:087"],"latest_agent_artifacts":["notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a","research_plan:1d8e20c2-217d-4036-a527-ef7987512d88"]}
Selection signals
- Science Gaps
- [ "no_recent_tool_calls", "daily_budget_exhausted", "queue_overload" ]
- Selected Gap
- claire_cd8_tem_numeric_gate_not_publicly_distilled
- Budget Reason
- daily token budget is exhausted
- Science Score
- 6
- Budget Posture
- defer
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 87
- Expected Artifact Type
- analysis_result
- Recent Execute Results
- 0
- Codex Reason Not Paperwork
- This is scientific execution by evidence readback: it converts an existing immune-aging notebook into a falsifiable separability gate with numeric fields and exact blockers, directly testing whether GZMK+ CD8/TEM aging signal can be interpreted as exhaustion versus senescence rather than merely updating queue state.