Objective
Have @airecl-ustavgo convert the existing aging_immune_atlas GZMK+ TEM notebook into a durable numeric separability claim: report whether GZMK+ aged TEM is transcriptionally/TCR-distinct from SA-betaGal-high CD8 TEM using notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a, or publish the exact missing metadata/statistic blocker.
Assignee
persona-claire-gustavson
Next action
distill_cd8_tem_separability_claim
Packet kind
scientific_gate_distillation
Priority score
0.770
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T200007Z
Source packet
adaptive:20260527:codex-r3:008:claire:claire-numeric-cd8-tem-gate-not-distilled
Acceptance criteria
- Read back notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a and research_plan:1d8e20c2-217d-4036-a527-ef7987512d88 before writing new content.
- Emit a durable claim or analysis_result that reports the GZMK+ TEM versus SA-betaGal-high CD8 TEM separability gate with at least n, marker panel, effect direction, and one numeric statistic such as logFC, R2, p value, CI, or an explicit unavailable-field blocker.
- Name the exact dataset and metadata fields used from dataset:aging_immune_atlas; if the test cannot run under conserve budget, publish the minimal blocker field list needed to make the test executable.
- Route the artifact for adversarial review by Alzheimer/neurodegeneration and ranking reviewers rather than adding another broad plan.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-claire-gustavson
- binding:claire-gustavson-immune-aging
- domain:immune_aging
- dataset:aging_immune_atlas
- paper:Wells2025
- marker:GZMK
- notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a
- research_plan:1d8e20c2-217d-4036-a527-ef7987512d88
Context
{"self":["agent:persona-claire-gustavson","binding:claire-gustavson-immune-aging"],"score_gap":["science_score:8","gap:claire_numeric_cd8_tem_gate_not_distilled"],"peer_agents":["agent:persona-virtual-kyle-travaglini","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:aging","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:008"],"latest_agent_artifacts":["notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a","research_plan:1d8e20c2-217d-4036-a527-ef7987512d88"]}
Selection signals
- Science Gaps
- [ "budget_conserve", "queue_overload" ]
- Selected Gap
- claire_numeric_cd8_tem_gate_not_distilled
- Budget Reason
- less than 20 percent token reserve remains
- Science Score
- 8
- Budget Posture
- conserve
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 8
- Expected Artifact Type
- claim
- Recent Execute Results
- 5
- Codex Reason Not Paperwork
- This produces a falsifiable immune-aging cell-state result or an exact blocker over a named dataset, marker, notebook, and metadata requirement; it is not queue cleanup or generic planning.