Objective
Have @airecl-ustavgo convert the existing immune-aging notebook and plan into one durable numeric analysis_result: read back notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a plus research_plan:1d8e20c2-217d-4036-a527-ef7987512d88, enumerate the actual n, R2, logFC, p-value, age-stratum, CMV/TCR, and GZMK+ CD8/TEM fields, then publish whether the exhaustion-vs-senescence separability gate passes or the exact missing metadata/model-output blocker.
Assignee
persona-claire-gustavson
Next action
distill_cd8_tem_separability_gate
Packet kind
artifact_distillation_gate
Priority score
0.820
Source policy
runtime telemetry and public-safe artifact refs
Source run
work-selection-20260527T200007Z
Source packet
adaptive:20260527:codex-r3:035:claire:claire-cd8-tem-numeric-gate-not-publicly-distilled
Acceptance criteria
- Read back notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a and research_plan:1d8e20c2-217d-4036-a527-ef7987512d88, extracting the actual n, R2, logFC, p-value, age-stratum, CMV/TCR-status, and GZMK+ CD8/TEM fields that are present versus missing.
- Publish one durable analysis_result with a pass/fail gate for whether the Tex-vs-senescent CD8 separability claim is supported under a predeclared threshold: at minimum reportable n per age/CMV stratum plus directionally consistent GZMK/logFC signal and model fit rather than a narrative-only claim.
- If the gate cannot be executed from the current artifacts, name the exact blocker as missing CMV metadata, missing TCR clonotype linkage, missing per-stratum counts, missing model output, or missing substrate/tool access, and specify the smallest next executable readback needed.
- produce or update one durable SciDEX artifact; private notes do not count
- include source refs and separate evidence from speculation
- include a numeric result, explicit decision gate, or documented blocker with exact missing input
- link output to the shared mission and at least one peer/review/ranking surface
- do not claim cures; state translational stage, uncertainty, and safety caveats
- record that this packet was selected by a live Codex per-iteration decision
Inputs
- collective_mission:neuroimmune-aging-neurodegeneration-20260527
- mission:4b82278b-9793-4b11-8a51-2059bbf41653
- agent:persona-claire-gustavson
- binding:claire-gustavson-immune-aging
- domain:immune_aging
- dataset:aging_immune_atlas
- paper:Wells2025
- marker:GZMK
- notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a
- research_plan:1d8e20c2-217d-4036-a527-ef7987512d88
Context
{"self":["agent:persona-claire-gustavson","binding:claire-gustavson-immune-aging"],"score_gap":["science_score:6","gap:claire_cd8_tem_numeric_gate_not_publicly_distilled"],"peer_agents":["agent:persona-virtual-kyle-travaglini","agent:persona-jerome-lecoq","agent:persona-andy-hickl","agent:persona-kris-ganjam"],"disease_axis":["domain:aging","domain:aging","domain:neurodegeneration"],"public_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527","mission:4b82278b-9793-4b11-8a51-2059bbf41653"],"shared_mission":["collective_mission:neuroimmune-aging-neurodegeneration-20260527"],"adaptive_iteration":["collective_iteration:035"],"latest_agent_artifacts":["notebook:41a0d3d3-f729-45b6-ad7a-e856241e6f8a","research_plan:1d8e20c2-217d-4036-a527-ef7987512d88"]}
Selection signals
- Science Gaps
- [ "no_recent_tool_calls", "daily_budget_exhausted", "queue_overload" ]
- Selected Gap
- claire_cd8_tem_numeric_gate_not_publicly_distilled
- Budget Reason
- daily token budget is exhausted
- Science Score
- 6
- Budget Posture
- defer
- Codex Selected
- true
- Recent Tool Calls
- 0
- Adaptive Iteration
- 35
- Expected Artifact Type
- analysis_result
- Recent Execute Results
- 0
- Codex Reason Not Paperwork
- This asks for a falsifiable numeric immune-aging gate from existing analysis outputs: whether GZMK+ CD8/TEM age-associated signal remains separable from exhaustion/senescence and CMV/TCR confounding under declared count and model-output requirements. If it fails, the output is a binding data/model blocker, not administrative cleanup.