Details

scope
mouse + marmoset + human MOp/M1; snRNA-seq + MERFISH + epigenomic
claim_text
BICCN (2021) integrated snRNA-seq datasets across mouse, marmoset and human primary motor cortex (MOp/M1) to identify 45 conserved t-types including 24 GABAergic types within a consensus cross-species taxonomy.
section_id
section_01
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-01-introduction
source_kind
review_finding
source_path
evidence/section_01_evidence_package.json
source_span
To establish a consensus classification of MOp and M1 cell types among mouse, human and marmoset, we integrated snRNA-seq datasets across species and identified 45 conserved t-types, including 24 GABAergic.
study_system
mouse + marmoset + human MOp/M1; snRNA-seq + MERFISH + epigenomic
section_title
Introduction
evidence_summary
Cross-species snRNA-seq integration of MOp/M1 yielded 45 conserved t-types; CGE-derived subclasses (Lamp5, Sncg, Vip) preserved across all three species; human cell-type taxonomy 127 t-types, marmoset 94 t-types.
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
replicated
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-01-introduction
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
raw_fields
{
  "n": null,
  "doi": "10.1038/s41586-021-03950-0",
  "claim": "BICCN (2021) integrated snRNA-seq datasets across mouse, marmoset and human primary motor cortex (MOp/M1) to identify 45 conserved t-types including 24 GABAergic types within a consensus cross-species taxonomy.",
  "title": null,
  "cite_key": "Braininitiativecellcensusnetworkbiccn2021",
  "evidence": "Cross-species snRNA-seq integration of MOp/M1 yielded 45 conserved t-types; CGE-derived subclasses (Lamp5, Sncg, Vip) preserved across all three species; human cell-type taxonomy 127 t-types, marmoset 94 t-types.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse + marmoset + human MOp/M1; snRNA-seq + MERFISH + epigenomic",
  "target_section": "section_02",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 11,
  "claim_source_sentence": "To establish a consensus classification of MOp and M1 cell types among mouse, human and marmoset, we integrated snRNA-seq datasets across species and identified 45 conserved t-types, including 24 GABAergic."
}
source_refs
[
  "paper:paper-pm-34616075"
]
evidence_refs
[
  {
    "ref": "paper:paper-pm-34616075"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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