Details
- scope
- mouse V1
- section_id
- section_01
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-01-introduction
- source_kind
- review_finding
- source_path
- evidence/section_01_evidence_package.json
- study_system
- mouse V1
- section_title
- Introduction
- evidence_summary
- Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- contested
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-01-introduction
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_01_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (6)
- claim_text
Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.
- raw_fields
{ "n": null, "doi": "10.7554/elife.14985", "year": "2016", "claim": "Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.", "title": null, "journal": "eLife", "cite_key": "Pakan2016", "evidence": "Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex", "effect_size": null, "text_access": "abstract_only", "first_author": "Pakan", "study_system": "mouse V1", "_source_cluster": "cluster_06_disinhibition_circuit", "author_list_short": "Pakan, Lowe, Dylda", "replication_status": "contested", "_collapsed_provenance": [ { "doi": "10.7554/elife.14985", "claim": "In-vivo two-photon imaging in mouse V1 showed that during visual stimulation locomotion increases activity of VIP, SST and PV interneurons simultaneously — directly contradicting the simple VIP→SST disinhibition model — and that locomotion modulation is context-dependent, with the highest proportion of context-sensitive cells among SST neurons.", "source_cluster": "cluster_01_molecular_taxonomy", "source_cluster_index": 70 } ], "_source_cluster_index": 12, "claim_source_sentence": "Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.", "replication_evidence_dois": [ "10.1016/j.cell.2014.01.050", "10.1016/j.neuron.2018.03.037" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-acf576c0a2ed" ]
- source_span
Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model.
- evidence_refs
[ { "ref": "paper:paper-acf576c0a2ed" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }