Horizontal L2/3-L2/3 connections between neighboring barrel columns in the deve…

Details

scope: Developing mouse barrel cortex (acute slices, L2/3 horizontal connections between neighboring columns, before critical period)
claim_text: Horizontal L2/3-L2/3 connections between neighboring barrel columns in the developing mouse cortex exhibit all-LTP STDP (unimodal LTP regardless of pre-post or post-pre timing) before the critical period.
section_id: section_12
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-12-plasticity
source_kind: review_finding
source_path: evidence/section_12_evidence_package.json
source_span: Here, we first show that the L2/3 horizontal connections exhibit all-LTP STDP when axons are extending during synapse formation before the critical period.
study_system: Developing mouse barrel cortex (acute slices, L2/3 horizontal connections between neighboring columns, before critical period)
section_title: 12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning
evidence_summary: Pairing-induced STDP at L2/3 horizontal synapses produced LTP for both pre-post and post-pre timing windows; pre-post LTP required NMDA receptors (blocked by APV), while post-pre LTP did not.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-12-plasticity
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.3390/cells14181459",
  "claim": "Horizontal L2/3-L2/3 connections between neighboring barrel columns in the developing mouse cortex exhibit all-LTP STDP (unimodal LTP regardless of pre-post or post-pre timing) before the critical period.",
  "cite_key": "Itami2025",
  "evidence": "Pairing-induced STDP at L2/3 horizontal synapses produced LTP for both pre-post and post-pre timing windows; pre-post LTP required NMDA receptors (blocked by APV), while post-pre LTP did not.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Developing mouse barrel cortex (acute slices, L2/3 horizontal connections between neighboring columns, before critical period)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Here, we first show that the L2/3 horizontal connections exhibit all-LTP STDP when axons are extending during synapse formation before the critical period.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-7e9548acfa0a"
]

evidence_refs

[
  {
    "ref": "paper:paper-7e9548acfa0a"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

Horizontal L2/3-L2/3 connections between neighboring barrel columns in the deve…

Details

Replication

Discussion