- claim_text
Tremblay et al. (2016) reviewed evidence that VIP+ cortical interneurons co-express subsidiary markers in distinct subpopulations: CCK in multipolar VIP cells, calretinin (CR) in irregular-spiking bipolar VIP/CR+ cells, and choline acetyltransferase (ChAT) in a small VIP/ChAT bipolar subgroup.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2016.06.033",
"claim": "Tremblay et al. (2016) reviewed evidence that VIP+ cortical interneurons co-express subsidiary markers in distinct subpopulations: CCK in multipolar VIP cells, calretinin (CR) in irregular-spiking bipolar VIP/CR+ cells, and choline acetyltransferase (ChAT) in a small VIP/ChAT bipolar subgroup.",
"title": null,
"cite_key": "Tremblay2016",
"evidence": "VIP IN subpopulations: VIP/CCK multipolar (basket-like), VIP/CR bipolar (irregular spiking), VIP/ChAT (cholinergic, upper layer). Intersectional Vip-flp × CR-cre genetics confirmed VIP/CR cells enriched in irregular-spiking bipolar phenotype (He et al. 2016).",
"effect_size": null,
"text_access": "fulltext",
"study_system": "rodent neocortex (review)",
"target_section": "section_11",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replicated",
"_source_cluster_index": 20,
"claim_source_sentence": "Multipolar VIP INs include VIP INs expressing CCK and a group of L6 multipolar VIP cells with an intralaminar axon spanning laterally. Some Vip INs also express the ACh synthetizing enzyme choline acetyl transferase (ChAT). Vip CR+ INs behave differently than Vip CR- neurons in terms of the role of activity in their migration and maturation."
}- source_refs
[
"paper:paper-53c8505de50f"
]
- source_span
Multipolar VIP INs include VIP INs expressing CCK and a group of L6 multipolar VIP cells with an intralaminar axon spanning laterally. Some Vip INs also express the ACh synthetizing enzyme choline acetyl transferase (ChAT). Vip CR+ INs behave differently than Vip CR- neurons in terms of the role of activity in their migration and maturation.
- evidence_refs
[
{
"ref": "paper:paper-53c8505de50f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}- evidence_summary
VIP IN subpopulations: VIP/CCK multipolar (basket-like), VIP/CR bipolar (irregular spiking), VIP/ChAT (cholinergic, upper layer). Intersectional Vip-flp × CR-cre genetics confirmed VIP/CR cells enriched in irregular-spiking bipolar phenotype (He et al. 2016).