Human cortical 'rosehip' cells, originally described as a primate-specific laye…

Human cortical 'rosehip' cells, originally described as a primate-specific layer-1 GABAergic interneuron subtype, correspond transcriptomically to the Inh L1-4 LAMP5 LCP2 type — although they are present across multiple cortical layers despite their initial L1 description, refining their developmental and morphological classification within the CGE-derived LAMP5/PAX6 subclass.

{
  "n": null,
  "doi": "10.1038/s41586-019-1506-7",
  "claim": "Human cortical 'rosehip' cells, originally described as a primate-specific layer-1 GABAergic interneuron subtype, correspond transcriptomically to the Inh L1-4 LAMP5 LCP2 type — although they are present across multiple cortical layers despite their initial L1 description, refining their developmental and morphological classification within the CGE-derived LAMP5/PAX6 subclass.",
  "title": null,
  "cite_key": "Hodge2019",
  "evidence": "Cross-mapping of published rosehip-cell single-cell RNA-seq (Boldog 2018) to human MTG taxonomy; layer-resolved snRNA-seq.",
  "effect_size": "1 transcriptomic type (Inh L1-4 LAMP5 LCP2) corresponds to rosehip cells; spans L1-L4",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "human MTG (snRNA-seq); cross-reference to Boldog 2018 rosehip discovery",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replicated",
  "_source_cluster_index": 110,
  "claim_source_sentence": "Inh L1-4 LAMP5 LCP2 matched rosehip cells ( Extended Data Fig. 5d ), discovered in L1 14 but present in all cortical layers.",
  "replication_evidence_dois": [
    "10.1038/s41593-018-0205-2"
  ],
  "effect_size_source_sentence": "Inh L1-4 LAMP5 LCP2 matched rosehip cells ( Extended Data Fig. 5d ), discovered in L1 14 but present in all cortical layers."
}

[
  "paper:paper-pm-31435019"
]

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  }
]

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