Multiphoton-holographic activation of orientation-selective ensembles in mouse…

Multiphoton-holographic activation of orientation-selective ensembles in mouse V1 recruits widespread functionally related neurons and is sufficient to drive correct behavioural discrimination, with layer-5 ensembles as effective as larger layer-2/3 ensembles.

{
  "n": 0,
  "doi": "10.1126/science.aaw5202",
  "claim": "Multiphoton-holographic activation of orientation-selective ensembles in mouse V1 recruits widespread functionally related neurons and is sufficient to drive correct behavioural discrimination, with layer-5 ensembles as effective as larger layer-2/3 ensembles.",
  "cite_key": "Marshel2019",
  "evidence": "Multiplexed multiphoton holography (MultiSLM) plus a red-shifted channelrhodopsin in awake behaving mice performing visual discrimination.",
  "effect_size": "L5 ensembles equivalent to larger L2/3 ensembles in driving behaviour",
  "text_access": "abstract_only",
  "study_system": "awake behaving mouse V1; multiplexed multiphoton holography (ChRmine) + 2-photon imaging",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Stimulating a critical number of stimulus-orientation-selective neurons drove widespread recruitment of functionally related neurons, a process enhanced by (but not requiring) orientation-discrimination task learning.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Cortical layer-specific dynamics were apparent, as emergent neuronal activity asymmetrically propagated from layer 2/3 to layer 5, and smaller layer 5 ensembles were as effective as larger layer 2/3 ensembles in eliciting orientation discrimination behavior."
}

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