Details
- scope
- D1-Cre and D2-Cre BAC transgenic mice, AAV-DIO-ChR2-YFP into dorsomedial striatum
- claim_text
- Bilateral optogenetic activation of indirect-pathway striatal MSNs in D2-Cre mice produces a parkinsonian motor phenotype, while activation of direct-pathway MSNs in D1-Cre mice increases locomotion.
- section_id
- section_11
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- effect_size
- 2
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- Bilateral excitation of indirect-pathway MSNs elicited a parkinsonian state, distinguished by increased freezing, bradykinesia, and decreased locomotor initiations.
- study_system
- D1-Cre and D2-Cre BAC transgenic mice, AAV-DIO-ChR2-YFP into dorsomedial striatum
- section_title
- Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
- evidence_summary
- Cre-dependent AAV-DIO-ChR2 in dorsomedial striatum of D1-Cre and D2-Cre BAC transgenic mice; optogenetic activation of either pathway during free behavior.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/nature09159", "claim": "Bilateral optogenetic activation of indirect-pathway striatal MSNs in D2-Cre mice produces a parkinsonian motor phenotype, while activation of direct-pathway MSNs in D1-Cre mice increases locomotion.", "cite_key": "Kravitz2010", "evidence": "Cre-dependent AAV-DIO-ChR2 in dorsomedial striatum of D1-Cre and D2-Cre BAC transgenic mice; optogenetic activation of either pathway during free behavior.", "effect_size": "2", "text_access": "fulltext", "study_system": "D1-Cre and D2-Cre BAC transgenic mice, AAV-DIO-ChR2-YFP into dorsomedial striatum", "source_cluster_id": "cluster_10", "replication_status": "independently_replicated", "claim_source_sentence": "Bilateral excitation of indirect-pathway MSNs elicited a parkinsonian state, distinguished by increased freezing, bradykinesia, and decreased locomotor initiations.", "replication_evidence_dois": [ "10.1038/nature11846" ], "effect_size_source_sentence": "Bilateral optogenetic activation of indirect-pathway striatal MSNs in D2-Cre mice produces a parkinsonian motor phenotype, while activation of direct-pathway MSNs in D1-Cre mice increases locomotion." }- source_refs
[ "paper:5c30e0b5-d627-4661-b656-d88df1b47830" ]
- evidence_refs
[ { "ref": "paper:5c30e0b5-d627-4661-b656-d88df1b47830" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }