Synaptic strengths between L2/3 V1 pyramidal pairs follow a heavy-tailed distri…

{
  "n": 0,
  "doi": "10.1038/nature14182",
  "claim": "Synaptic strengths between L2/3 V1 pyramidal pairs follow a heavy-tailed distribution; the few strong connections link neurons with the most correlated visual responses, while weak connections dominate uncorrelated pairs.",
  "cite_key": "Cossell2015",
  "evidence": "Paired recordings between L2/3 pyramidal neurons whose visual response correlations were measured in vivo. Strong-connection rule extracted from EPSP-amplitude distributions vs signal correlation.",
  "effect_size": "Connection amplitudes span ~2 orders of magnitude; strongest tail confined to highly correlated pairs",
  "text_access": "abstract_only",
  "study_system": "mouse V1, L2/3 pyramidal neurons; in vivo 2-photon imaging plus in vitro paired patch recordings",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Here we reveal that the strength of connections between layer 2/3 (L2/3) pyramidal neurons in mouse primary visual cortex (V1) obeys a simple rule--the few strong connections occur between neurons with most correlated responses, while only weak connections link neurons with uncorrelated responses.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature09880",
    "10.1038/nature17192"
  ],
  "effect_size_source_sentence": "Excitatory connection amplitudes between pairs of cortical neurons vary over two orders of magnitude, comprising only very few strong connections among many weaker ones."
}

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  "paper:paper-c4ad527c9bfb"
]

Here we reveal that the strength of connections between layer 2/3 (L2/3) pyramidal neurons in mouse primary visual cortex (V1) obeys a simple rule--the few strong connections occur between neurons with most correlated responses, while only weak connections link neurons with uncorrelated responses.

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