In mouse barrel cortex, long-range and local excitatory axons innervate distinc…

In mouse barrel cortex, long-range and local excitatory axons innervate distinct subcellular dendritic domains of L3, L5A and L5B pyramidal neurons, with thalamic, M1-motor and local inputs arrayed in an orderly pattern along the apical axis.

{
  "n": 0,
  "doi": "10.1038/nature07709",
  "claim": "In mouse barrel cortex, long-range and local excitatory axons innervate distinct subcellular dendritic domains of L3, L5A and L5B pyramidal neurons, with thalamic, M1-motor and local inputs arrayed in an orderly pattern along the apical axis.",
  "cite_key": "Petreanu2009",
  "evidence": "ChR2-assisted circuit mapping (subcellular CRACM) in acute mouse barrel-cortex slices; ChR2 expression in two thalamic nuclei, whisker motor cortex (vM1) and local L2/3 neurons; whole-cell recording from L3, L5A and L5B pyramidal neurons.",
  "effect_size": "Distinct apical/basal subcellular input domains; exact map values reported in figures (no single-number summary provided in abstract).",
  "text_access": "abstract_only",
  "study_system": "mouse barrel cortex, acute slice, ChR2-assisted circuit mapping (subcellular CRACM) onto L3, L5A and L5B pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Within the dendritic arborizations of L3 cells, individual inputs impinged onto distinct single domains. These domains were arrayed in an orderly, monotonic pattern along the apical axis: axons from more central origins targeted progressively higher regions of the apical dendrites.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nn1891",
    "10.1038/nature08935"
  ],
  "effect_size_source_sentence": null
}

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  "paper:914d374f-2785-4b45-b1ed-71edc0641508"
]

Within the dendritic arborizations of L3 cells, individual inputs impinged onto distinct single domains. These domains were arrayed in an orderly, monotonic pattern along the apical axis: axons from more central origins targeted progressively higher regions of the apical dendrites.

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