Paired recordings between mouse auditory L2/3 pyramidal cells and identified L5…

Paired recordings between mouse auditory L2/3 pyramidal cells and identified L5B corticocollicular (PT) vs corticocallosal (IT) neurons reveal equal connection probability/amplitude but qualitatively different short-term plasticity: L2/3→corticocollicular synapses do not depress while L2/3→corticocallosal synapses depress substantially.

{
  "n": 0,
  "doi": "10.1523/jneurosci.0836-14.2015",
  "claim": "Paired recordings between mouse auditory L2/3 pyramidal cells and identified L5B corticocollicular (PT) vs corticocallosal (IT) neurons reveal equal connection probability/amplitude but qualitatively different short-term plasticity: L2/3→corticocollicular synapses do not depress while L2/3→corticocallosal synapses depress substantially.",
  "cite_key": "Joshi2015",
  "evidence": "Paired patch recordings in mouse auditory cortex slices with retrograde labeling of corticocollicular and corticocallosal L5B neurons.",
  "effect_size": "Identical static connectivity (P, amplitude) but opposite short-term plasticity directions across L5B subclass.",
  "text_access": "abstract_only",
  "study_system": "mouse auditory cortex (AC); L2/3 pyramidal → L5B corticocollicular (PT) and corticocallosal (IT); paired patch + retrograde",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "In paired recordings between single L2/3 and labeled L5B neurons, the probabilities of connection, amplitude, latency, rise time, and decay time constant of the unitary EPSC were not different for L2/3→corticocollicular and L2/3→corticocallosal connections. However, short trains of unitary EPSCs showed no synaptic depression in L2/3→corticocollicular connections, but substantial depression in L2/3→corticocallosal connections.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-1434a55a9a22"
]

In paired recordings between single L2/3 and labeled L5B neurons, the probabilities of connection, amplitude, latency, rise time, and decay time constant of the unitary EPSC were not different for L2/3→corticocollicular and L2/3→corticocallosal connections. However, short trains of unitary EPSCs showed no synaptic depression in L2/3→corticocollicular connections, but substantial depression in L2/3→corticocallosal co...

[
  {
    "ref": "paper:paper-1434a55a9a22"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}