Outer radial glia (oRG) cells in human developing cortex express the LIF recept…

Outer radial glia (oRG) cells in human developing cortex express the LIF receptor (LIFR) at higher levels than other cortical cells; LIF treatment of cortical organoids and primary cortical tissue increases oRG proliferation AND increases inhibitory interneuron production, with the enhanced IN population transcriptionally resembling caudal ganglionic eminence (CGE)-derived INs.

{
  "n": null,
  "doi": "10.1016/j.stem.2023.08.009",
  "claim": "Outer radial glia (oRG) cells in human developing cortex express the LIF receptor (LIFR) at higher levels than other cortical cells; LIF treatment of cortical organoids and primary cortical tissue increases oRG proliferation AND increases inhibitory interneuron production, with the enhanced IN population transcriptionally resembling caudal ganglionic eminence (CGE)-derived INs.",
  "title": null,
  "cite_key": "Andrews2023",
  "evidence": "Pluripotent stem cell-derived dorsal forebrain organoids + primary human cortical tissue cultures + isolated primary oRG cultures with LIF.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "fulltext",
  "key_entities": [
    "LIF",
    "LIFR",
    "oRG",
    "outer radial glia",
    "CGE",
    "interneuron",
    "NR2F2",
    "PROX1",
    "MEIS2",
    "PAX6",
    "human",
    "organoid"
  ],
  "study_system": "human cortical organoids + primary cortical tissue + isolated oRG cells",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 128,
  "claim_source_sentence": "Surprisingly, LIF treatment also increases the production of inhibitory interneurons (INs) in cortical cultures. Comparative transcriptomic analysis identifies that the enhanced IN population resembles INs produced in the caudal ganglionic eminence. ... They find that LIF shifts oRG production toward inhibitory interneurons that resemble cells derived from the caudal ganglionic eminence, with implications for excitatory/inhibitory balance.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-14ad138608e3"
]

Surprisingly, LIF treatment also increases the production of inhibitory interneurons (INs) in cortical cultures. Comparative transcriptomic analysis identifies that the enhanced IN population resembles INs produced in the caudal ganglionic eminence. ... They find that LIF shifts oRG production toward inhibitory interneurons that resemble cells derived from the caudal ganglionic eminence, with implications for excita...

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