In mouse barrel cortex, VIP+ interneurons constitute approximately 13% of all G…

In mouse barrel cortex, VIP+ interneurons constitute approximately 13% of all GABAergic neurons; most are located in L2/3 (~60%); VIPcre/tdTomato mice are highly sensitive and specific for the entire VIP population, validating Cre-driver-based circuit dissection.

{
  "n": null,
  "doi": "10.1093/cercor/bhv202",
  "claim": "In mouse barrel cortex, VIP+ interneurons constitute approximately 13% of all GABAergic neurons; most are located in L2/3 (~60%); VIPcre/tdTomato mice are highly sensitive and specific for the entire VIP population, validating Cre-driver-based circuit dissection.",
  "title": null,
  "cite_key": "Pronneke2015",
  "evidence": "Quantitative tdTomato vs Vip-FISH and α-VIP immunohistochemistry in VIPcre/tdTomato barrel cortex.",
  "effect_size": "~13% of GABAergic neurons in barrel cortex are VIP+; ~60% in L2/3.",
  "text_access": "fulltext",
  "study_system": "mouse barrel cortex (VIPcre/tdTomato)",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replicated",
  "_source_cluster_index": 22,
  "claim_source_sentence": "In the barrel cortex, approximately 13% of all GABAergic neurons are VIP expressing.",
  "replication_evidence_dois": [
    "10.1016/j.cell.2017.09.020"
  ],
  "effect_size_source_sentence": "Most VIP neurons are found in layer II/III (∼60%), whereas app"
}

[
  "paper:paper-8e91417bef90"
]

[
  {
    "ref": "paper:paper-8e91417bef90"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}