Patch-clamp activation of single L2/3 or L4 pyramidal neurons in mouse V1 produ…

Patch-clamp activation of single L2/3 or L4 pyramidal neurons in mouse V1 produces only sparse single-cell followers (<0.75% of nearby L2/3 cells within ~200 μm) — substantially fewer than canonical-microcircuit pairwise estimates would imply.

{
  "n": 0,
  "doi": "10.3389/fncir.2018.00029",
  "claim": "Patch-clamp activation of single L2/3 or L4 pyramidal neurons in mouse V1 produces only sparse single-cell followers (<0.75% of nearby L2/3 cells within ~200 μm) — substantially fewer than canonical-microcircuit pairwise estimates would imply.",
  "cite_key": "Meyer2018",
  "evidence": "Two-photon calcium imaging in mouse V1 with single-cell patch-clamp stimulation of L2/3 or L4 pyramidal neurons in vivo.",
  "effect_size": "<0.75% reliably activated followers within 200 μm radius",
  "text_access": "abstract_only",
  "study_system": "mouse V1 L2/3 in vivo, 2P calcium + patch-clamp single-cell stimulation",
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  "claim_source_sentence": "Using this approach, we found only a small fraction (<0.75%) of L2/3 cells to be significantly activated within a radius of ~200 μm from a stimulated neighboring L2/3 pyramidal cell. This fraction did not change significantly in the awake vs. the lightly anesthetized state, nor when stimulating L2/3 vs. underlying L4 pyramidal neurons.",
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  "effect_size_source_sentence": "Using this approach, we found only a small fraction (<0.75%) of L2/3 cells to be significantly activated within a radius of ~200 μm from a stimulated neighboring L2/3 pyramidal cell."
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]

Using this approach, we found only a small fraction (<0.75%) of L2/3 cells to be significantly activated within a radius of ~200 μm from a stimulated neighboring L2/3 pyramidal cell. This fraction did not change significantly in the awake vs. the lightly anesthetized state, nor when stimulating L2/3 vs. underlying L4 pyramidal neurons.

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