- claim_text
Smith et al. (2019) revealed that single-cell transcriptomes from mouse cortical neurons encode dense, type-specific intracortical neuropeptide signaling networks: every cortical neuron type expresses multiple NPP and NP-GPCR genes, with VIP, SST, NPY, CCK serving as canonical interneuron-class markers consistent with a long history of immunohistochemical typing.
- raw_fields
{
"n": null,
"doi": "10.7554/elife.47889",
"claim": "Smith et al. (2019) revealed that single-cell transcriptomes from mouse cortical neurons encode dense, type-specific intracortical neuropeptide signaling networks: every cortical neuron type expresses multiple NPP and NP-GPCR genes, with VIP, SST, NPY, CCK serving as canonical interneuron-class markers consistent with a long history of immunohistochemical typing.",
"title": null,
"cite_key": "Smith2019",
"evidence": "Analysis of Tasic 2018 and Zeisel 2018 scRNA-seq data: 18 NPP genes including Vip and 29 NP-GPCR genes show type-specific expression; VIP/CCK/SST/NPY anchor classical immunohistochemical interneuron classification within transcriptomic taxonomy.",
"effect_size": null,
"text_access": "fulltext",
"study_system": "mouse cortex; scRNA-seq reanalysis (Tasic 2018, Zeisel 2018)",
"target_section": "section_02",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replicated",
"_source_cluster_index": 43,
"claim_source_sentence": "It is well established that certain neuropeptides, including vasoactive intestinal peptide (VIP), somatostatin (SST), neuropeptide Y (NPY), substance P, and cholecystokinin (CCK), are detectible at high levels in particular subsets of GABAergic cortical neurons. These heat maps also show that every neuron type expresses multiple NPP and NP-GPCR genes and that each of the NPP and NP-GPCR genes is expressed in multiple neuron types."
}- source_refs
[
"paper:paper-pm-31710287"
]
- source_span
It is well established that certain neuropeptides, including vasoactive intestinal peptide (VIP), somatostatin (SST), neuropeptide Y (NPY), substance P, and cholecystokinin (CCK), are detectible at high levels in particular subsets of GABAergic cortical neurons. These heat maps also show that every neuron type expresses multiple NPP and NP-GPCR genes and that each of the NPP and NP-GPCR genes is expressed in multipl...
- evidence_refs
[
{
"ref": "paper:paper-pm-31710287"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}- evidence_summary
Analysis of Tasic 2018 and Zeisel 2018 scRNA-seq data: 18 NPP genes including Vip and 29 NP-GPCR genes show type-specific expression; VIP/CCK/SST/NPY anchor classical immunohistochemical interneuron classification within transcriptomic taxonomy.