Details

scope
Mouse primary visual cortex; anterograde + retrograde viral tracing of horizontal connectivity; M2 muscarinic receptor immunolabelling
section_id
section_04
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
effect_size
Long-range horizontal contacts cluster in M2- interpatches, overlapping apical dendrites of L2/3 and L5 projection cells (qualitative).
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-04-translaminar
source_kind
review_finding
source_path
evidence/section_04_evidence_package.json
study_system
Mouse primary visual cortex; anterograde + retrograde viral tracing of horizontal connectivity; M2 muscarinic receptor immunolabelling
section_title
4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections
evidence_summary
Combined anterograde and retrograde viral tracing in mouse V1 with cross-registration against M2 muscarinic-receptor patches.
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
single_study
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-04-translaminar
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (6)
claim_text
Within mouse V1, long-range horizontal connections are patchy and terminate preferentially in M2 muscarinic-acetylcholine-receptor-negative interpatches, overlapping with apical dendrites of L2/3 and L5 projection cells to form module-selective horizontal–vertical loops.
raw_fields
{
  "n": 0,
  "doi": "10.3389/fnana.2024.1364675",
  "claim": "Within mouse V1, long-range horizontal connections are patchy and terminate preferentially in M2 muscarinic-acetylcholine-receptor-negative interpatches, overlapping with apical dendrites of L2/3 and L5 projection cells to form module-selective horizontal–vertical loops.",
  "cite_key": "Burkhalter2024",
  "evidence": "Combined anterograde and retrograde viral tracing in mouse V1 with cross-registration against M2 muscarinic-receptor patches.",
  "effect_size": "Long-range horizontal contacts cluster in M2- interpatches, overlapping apical dendrites of L2/3 and L5 projection cells (qualitative).",
  "text_access": "abstract_only",
  "study_system": "Mouse primary visual cortex; anterograde + retrograde viral tracing of horizontal connectivity; M2 muscarinic receptor immunolabelling",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "The long connections were patchy and terminated preferentially in M2 muscarinic acetylcholine receptor-negative (M2-) interpatches. Anterogradely labeled inputs overlapped in M2-interpatches with apical dendrites of retrogradely labeled L2/3 and L5 cells, forming module-selective loops between topographically distant locations.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-236876dbc518"
]
source_span
The long connections were patchy and terminated preferentially in M2 muscarinic acetylcholine receptor-negative (M2-) interpatches. Anterogradely labeled inputs overlapped in M2-interpatches with apical dendrites of retrogradely labeled L2/3 and L5 cells, forming module-selective loops between topographically distant locations.
evidence_refs
[
  {
    "ref": "paper:paper-236876dbc518"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

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