Callosal projections from mouse somatosensory cortex L2/3 axons connect with L5…

Details

scope: mouse barrel/somatosensory cortex, acute slices, ChR2-assisted circuit mapping (CRACM) of L2/3 axons onto L2/3, L4, L5, L6 targets in ipsilateral and contralateral cortex
claim_text: Callosal projections from mouse somatosensory cortex L2/3 axons connect with L5, L2/3 and L6 — but not L4 — in both ipsilateral and contralateral cortex, with the L2/3→L5 projection stronger than L2/3→L2/3.
section_id: section_04
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
effect_size: L2/3→L5 stronger than L2/3→L2/3; L4 not contacted; quantitative input maps provided in figures.
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-04-translaminar
source_kind: review_finding
source_path: evidence/section_04_evidence_package.json
source_span: L2/3 axons connect with neurons in L5, L2/3 and L6, but not L4, in both ipsilateral and contralateral cortex. In both hemispheres the L2/3-to-L5 projection is stronger than the L2/3-to-L2/3 projection.
study_system: mouse barrel/somatosensory cortex, acute slices, ChR2-assisted circuit mapping (CRACM) of L2/3 axons onto L2/3, L4, L5, L6 targets in ipsilateral and contralateral cortex
section_title: 4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections
evidence_summary: ChR2-assisted circuit mapping (CRACM) in mouse somatosensory cortex slices; ChR2 delivered to L2/3 pyramidal axons in vivo; photostimulation combined with whole-cell recording in ipsi- and contralateral hemisphere.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-04-translaminar
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/nn1891",
  "claim": "Callosal projections from mouse somatosensory cortex L2/3 axons connect with L5, L2/3 and L6 — but not L4 — in both ipsilateral and contralateral cortex, with the L2/3→L5 projection stronger than L2/3→L2/3.",
  "cite_key": "Petreanu2007",
  "evidence": "ChR2-assisted circuit mapping (CRACM) in mouse somatosensory cortex slices; ChR2 delivered to L2/3 pyramidal axons in vivo; photostimulation combined with whole-cell recording in ipsi- and contralateral hemisphere.",
  "effect_size": "L2/3→L5 stronger than L2/3→L2/3; L4 not contacted; quantitative input maps provided in figures.",
  "text_access": "abstract_only",
  "study_system": "mouse barrel/somatosensory cortex, acute slices, ChR2-assisted circuit mapping (CRACM) of L2/3 axons onto L2/3, L4, L5, L6 targets in ipsilateral and contralateral cortex",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "L2/3 axons connect with neurons in L5, L2/3 and L6, but not L4, in both ipsilateral and contralateral cortex. In both hemispheres the L2/3-to-L5 projection is stronger than the L2/3-to-L2/3 projection.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature07709",
    "10.1038/nature08935"
  ],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:987379eb-ecdd-42eb-818f-383280a8fca9"
]

evidence_refs

[
  {
    "ref": "paper:987379eb-ecdd-42eb-818f-383280a8fca9"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

Callosal projections from mouse somatosensory cortex L2/3 axons connect with L5…

Details

Replication

Discussion