- claim_text
In mouse prelimbic prefrontal cortex layer 5, callosally evoked excitation and feedforward inhibition are much stronger onto cortico-thalamic (CT) neurons than onto neighbouring cortico-cortical (CC) neurons, with elevated inhibition at CT cells reflecting biased PV+ and SOM+ interneuron inputs.
- raw_fields
{
"n": null,
"doi": "10.1016/j.celrep.2017.12.073",
"claim": "In mouse prelimbic prefrontal cortex layer 5, callosally evoked excitation and feedforward inhibition are much stronger onto cortico-thalamic (CT) neurons than onto neighbouring cortico-cortical (CC) neurons, with elevated inhibition at CT cells reflecting biased PV+ and SOM+ interneuron inputs.",
"cite_key": "Anastasiades2018",
"evidence": "Optogenetic stimulation of contralateral cortex and paired whole-cell recordings of identified CC vs CT projection neurons in L5 of mouse prelimbic PFC.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse prelimbic PFC L5, retrogradely identified CC vs CT projection neurons",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "We find callosally evoked excitation and feedforward inhibition are much stronger at CT neurons compared to neighboring CC neurons. Elevated inhibition at CT neurons reflects biased synaptic inputs from parvalbumin and somatostatin positive interneurons.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-ec6edc3ce25f"
]
- source_span
We find callosally evoked excitation and feedforward inhibition are much stronger at CT neurons compared to neighboring CC neurons. Elevated inhibition at CT neurons reflects biased synaptic inputs from parvalbumin and somatostatin positive interneurons.
- evidence_refs
[
{
"ref": "paper:paper-ec6edc3ce25f"
}
]- source_policy
{
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"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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