- claim_text
In mouse prelimbic prefrontal cortex, callosal cortico-cortical inputs evoke much stronger excitation and feedforward inhibition onto layer-5 corticothalamic (CT) neurons than onto neighboring intratelencephalic cortico-cortical (CC) neurons.
- raw_fields
{
"n": null,
"doi": "10.1016/j.celrep.2017.12.073",
"claim": "In mouse prelimbic prefrontal cortex, callosal cortico-cortical inputs evoke much stronger excitation and feedforward inhibition onto layer-5 corticothalamic (CT) neurons than onto neighboring intratelencephalic cortico-cortical (CC) neurons.",
"cite_key": "Anastasiades2018",
"evidence": "Optogenetic activation of callosal axons with whole-cell recordings of retrogradely identified CC and CT L5 neurons in mouse PFC.",
"effect_size": "Callosal EPSCs and feedforward IPSCs are markedly larger at CT than at CC neurons (qualitative ratio).",
"text_access": "abstract_only",
"study_system": "Mouse prelimbic PFC, layer 5; optogenetics + slice physiology",
"argument_role": "supporting",
"replication_status": "single-study",
"claim_source_sentence": "We find callosally evoked excitation and feedforward inhibition are much stronger at CT neurons compared to neighboring CC neurons.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Elevated inhibition at CT neurons reflects biased synaptic inputs from parvalbumin and somatostatin positive interneurons."
}- source_refs
[
"paper:paper-ec6edc3ce25f"
]
- evidence_refs
[
{
"ref": "paper:paper-ec6edc3ce25f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}