Monocular deprivation in young-adult mice produces ocular-dominance shifts in h…

Monocular deprivation in young-adult mice produces ocular-dominance shifts in higher visual areas (LM, AL, PM) that are not uniform and are not simply inherited from V1: OD shifts are largest in LM and smallest in AL/PM, with different relative contributions of deprived- vs non-deprived-eye changes.

{
  "n": 0,
  "doi": "10.1093/cercor/bhad203",
  "claim": "Monocular deprivation in young-adult mice produces ocular-dominance shifts in higher visual areas (LM, AL, PM) that are not uniform and are not simply inherited from V1: OD shifts are largest in LM and smallest in AL/PM, with different relative contributions of deprived- vs non-deprived-eye changes.",
  "cite_key": "Craddock2023",
  "evidence": "Two-photon calcium imaging in V1b, LM, AL, PM of young-adult mice across MD and recovery showed area-specific OD shift magnitudes and recovery dynamics; only V1 recovered to pre-MD OD index within 2 weeks.",
  "effect_size": "OD index recovery to baseline within 2 weeks only in V1",
  "text_access": "abstract_only",
  "study_system": "Young-adult mouse higher visual areas V1b/LM/AL/PM (in vivo two-photon, MD paradigm)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "OD shifts following MD were greatest in LM and smallest in AL and PM; in LM and AL, these shifts were mediated primarily through a reduction of deprived-eye responses, in V1b and LM through an increase in response through the non-deprived eye.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "The OD index recovered to pre-MD levels within 2 weeks in V1 only."
}

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]

OD shifts following MD were greatest in LM and smallest in AL and PM; in LM and AL, these shifts were mediated primarily through a reduction of deprived-eye responses, in V1b and LM through an increase in response through the non-deprived eye.

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