Integrated neuroanatomical, physiological, and behavioural mapping of the mouse…

Integrated neuroanatomical, physiological, and behavioural mapping of the mouse medial prefrontal cortex identifies the dorsal peduncular area (DP), with deep (DPd) and superficial (DPs) layers, as a major component of the visceromotor cortex projecting directly to hypothalamic and brainstem structures.

{
  "n": 0,
  "doi": "10.1038/s41586-025-09360-w",
  "claim": "Integrated neuroanatomical, physiological, and behavioural mapping of the mouse medial prefrontal cortex identifies the dorsal peduncular area (DP), with deep (DPd) and superficial (DPs) layers, as a major component of the visceromotor cortex projecting directly to hypothalamic and brainstem structures.",
  "cite_key": "Hintiryan2025b",
  "evidence": "DP functions as a network hub integrating diverse cortical inputs and modulating goal-directed behaviour through largely unidirectional cortical information flow; mesoscale MPF connectome supports a unified model.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse mesoscale MPF connectome; DP/DPd/DPs and infralimbic projections to hypothalamic and brainstem visceromotor targets",
  "source_cluster_id": "cluster_11",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Here, using integrated neuroanatomical, physiological and behavioural approaches, we construct a comprehensive wiring diagram of the MPF, focused on the dorsal peduncular area (DP)-a poorly understood prefrontal area.",
  "replication_evidence_dois": [
    "10.1038/s41586-021-03993-3",
    "10.1038/s41467-021-22915-5"
  ],
  "effect_size_source_sentence": null
}

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]

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