Boldog et al. (2018) identified a human-specific cortical interneuron type ('ro…

Boldog et al. (2018) identified a human-specific cortical interneuron type ('rosehip cell') in human L1 not matching any mouse Vip/Sst/Pvalb cluster, while several other human L1 t-types (i6, i8, i9, i10, i11) matched mouse Vip+ types, supporting both conserved and human-specific elaboration of CGE-derived interneurons.

{
  "n": null,
  "doi": "10.1038/s41593-018-0205-2",
  "claim": "Boldog et al. (2018) identified a human-specific cortical interneuron type ('rosehip cell') in human L1 not matching any mouse Vip/Sst/Pvalb cluster, while several other human L1 t-types (i6, i8, i9, i10, i11) matched mouse Vip+ types, supporting both conserved and human-specific elaboration of CGE-derived interneurons.",
  "title": null,
  "cite_key": "Boldog2018",
  "evidence": "Patch-seq + snRNA-seq of human L1 cortex; rosehip type lacks mouse homolog; multiple VIP+ L1 clusters share marker signatures with mouse Vip+ types — confirming both conserved CGE-derived VIP types and human-specific innovations.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "human MTG L1; Patch-seq + snRNA-seq",
  "target_section": "section_02",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 33,
  "claim_source_sentence": "Many rosehip marker genes are not expressed in Smad3 or other Pvalb/Sst/Vip-negative mouse cell types or the complete set of mouse GABAergic types. Clusters i6, i8, i9, i11, and i10 matched mouse Vip+ clusters, and cluster i2 matched mouse Sst+ clusters."
}

[
  "paper:paper-pm-30150662"
]

Many rosehip marker genes are not expressed in Smad3 or other Pvalb/Sst/Vip-negative mouse cell types or the complete set of mouse GABAergic types. Clusters i6, i8, i9, i11, and i10 matched mouse Vip+ clusters, and cluster i2 matched mouse Sst+ clusters.

[
  {
    "ref": "paper:paper-pm-30150662"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}