Limbic-to-motor 'open loop' connections coexist with classical closed loops: ve…

{
  "n": 0,
  "doi": "10.7554/elife.49995",
  "claim": "Limbic-to-motor 'open loop' connections coexist with classical closed loops: ventral and dorsomedial striatum can send signals back to motor cortex without receiving direct inputs from it.",
  "cite_key": "Aoki2019",
  "evidence": "Rabies virus tracing in mice showed neurons in ventral, dorsomedial, and tail striatum project transsynaptically to M1/M2 without receiving M1/M2 direct inputs, confirming open-loop architecture in parallel with the canonical closed motor loop.",
  "effect_size": "",
  "text_access": "fulltext",
  "study_system": "mouse cortico-basal ganglia loops; rabies virus retrograde transsynaptic tracing",
  "source_cluster_id": "cluster_06",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "A similar pattern of labeling was observed following M2 injections, where VS, DMS and TS can target M2 without receiving its direct inputs ( Figure 1G–1I , Figure 1—figure supplement 2C, D and J ), confirming an open loop in addition to the closed motor loop.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-3023485dbad7"
]

A similar pattern of labeling was observed following M2 injections, where VS, DMS and TS can target M2 without receiving its direct inputs ( Figure 1G–1I , Figure 1—figure supplement 2C, D and J ), confirming an open loop in addition to the closed motor loop.

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Rabies virus tracing in mice showed neurons in ventral, dorsomedial, and tail striatum project transsynaptically to M1/M2 without receiving M1/M2 direct inputs, confirming open-loop architecture in parallel with the canonical closed motor loop.