- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2018.10.049",
"claim": "Higher-order thalamic (POm) inputs to S1 recruit VIP and PV interneurons while suppressing SST interneurons; the resulting VIP-mediated disinhibition is required for NMDAR-dependent LTP of L2/3 pyramidal neurons.",
"title": null,
"cite_key": "Williams2019",
"evidence": "Thalamocortical slice paired-pathway activation; VIP IN inactivation/blockade; LTP induction protocols.",
"effect_size": "Qualitative — VIP/PV activity increased, SST decreased; LTP abolished by VIP IN inactivation.",
"text_access": "abstract_only",
"study_system": "mouse S1 thalamocortical slice",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "single-study",
"_source_cluster_index": 6,
"claim_source_sentence": "Paired activation of cortical and higher-order thalamocortical inputs increased vasoactive intestinal peptide (VIP) and parvalbumin (PV) interneuron (IN) activity and decreased somatostatin (SST) IN activity, which together disinhibited the PNs.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-55f18434021b"
]
- source_span
Paired activation of cortical and higher-order thalamocortical inputs increased vasoactive intestinal peptide (VIP) and parvalbumin (PV) interneuron (IN) activity and decreased somatostatin (SST) IN activity, which together disinhibited the PNs.
- evidence_refs
[
{
"ref": "paper:paper-55f18434021b"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}